The DOI matches its Crossref record; 263 of the 263 references it cites were found in a registry or an index.
Canonical and Non-Canonical Notch Ligands
Open accessAbstract
Notch signaling induced by canonical Notch ligands is critical for normal embryonic development and tissue homeostasis through the regulation of a variety of cell fate decisions and cellular processes. Activation of Notch signaling is normally tightly controlled by direct interactions with ligand-expressing cells and dysregulated Notch signaling is associated with developmental abnormalities and cancer. While canonical Notch ligands are responsible for the majority of Notch signaling, a diverse group of structurally unrelated non-canonical ligands has also been identified that activate Notch and likely contribute to the pleiotropic effects of Notch signaling. Soluble forms of both canonical and non-canonical ligands have been isolated, some of which block Notch signaling and could serve as natural inhibitors of this pathway. Ligand activity can also be indirectly regulated by other signaling pathways at the level of ligand expression, serving to spatio-temporally compartmentalize Notch signaling activity and integrate Notch signaling into a molecular network that orchestrates developmental events. Here, we review the molecular mechanisms underlying the dual role of Notch ligands as activators and inhibitors of Notch signaling. Additionally, evidence that Notch ligands function independent of Notch are presented. We also discuss how ligand post-translational modification, endocytosis, proteolysis and spatio-temporal expression regulate their signaling activity.
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Cites
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Metadata
- Authors
- D’Souza, B., Meloty-Kapella, L., & Weinmaster, G.
- Venue
- Current Topics in Developmental Biology
- Publisher
- Elsevier
- Published
- 2010
- Volume
- 92
- Pages
- 73-129
- ISSN
- 0070-2153 (ISSN-L)
- OpenAlex
- W1508615665
- Cited by
- 362
- References
- 263
- FWCI
- 21.35
- Type
- book chapter
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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