The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration
Open accessAbstract
Recent lineage-tracing studies have produced conflicting results about whether the epicardium is a source of cardiac muscle cells during heart development. Here, we examined the developmental potential of epicardial tissue in zebrafish during both embryonic development and injury-induced heart regeneration. We found that upstream sequences of the transcription factor gene tcf21 activated robust, epicardium-specific expression throughout development and regeneration. Cre recombinase-based, genetic fate-mapping of larval or adult tcf21+ cells revealed contributions to perivascular cells, but not cardiomyocytes, during each form of cardiogenesis. Our findings indicate that natural epicardial fates are limited to non-myocardial cell types in zebrafish.
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Cites
Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation
Jopling, C., Sleep, E., Raya, M., Martí, M., Raya, A., & Belmonte, J. C. I. (2010) · Nature · doi:10.1038/nature08899 · Cited by 1,333
Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart
Zhou, B., Ma, Q., Rajagopal, S., Wu, S. M., Domian, I., Rivera-Feliciano, J., Jiang, D., von Gise, A., Ikeda, S., Chien, K. R., et al. (2008) · Nature · doi:10.1038/nature07060 · Cited by 1,019
Cited by
The zebrafish as a model for complex tissue regeneration
Gemberling, M., Bailey, T. J., Hyde, D. R., & Poss, K. D. (2013) · Trends in Genetics · doi:10.1016/j.tig.2013.07.003 · Cited by 566
Self-citationMending broken hearts: cardiac development as a basis for adult heart regeneration and repair
Xin, M., Olson, E. N., & Bassel-Duby, R. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3619 · Cited by 514
Epicardial FSTL1 reconstitution regenerates the adult mammalian heart
Wei, K., Serpooshan, V., Hurtado, C., Diez-Cuñado, M., Zhao, M., Maruyama, S., Zhu, W., Fajardo, G., Noseda, M., Nakamura, K., et al. (2015) · Nature · doi:10.1038/nature15372 · Cited by 489
Endocardial and Epicardial Epithelial to Mesenchymal Transitions in Heart Development and Disease
von Gise, A., & Pu, W. T. (2012) · Circulation Research · doi:10.1161/circresaha.111.259960 · Cited by 419
Wang, J., Panáková, D., Kikuchi, K., Holdway, J. E., Gemberling, M., Burris, J. S., Singh, S. P., Dickson, A. L., Lin, Y.-F., Sabeh, M. K., et al. (2011) · Development · doi:10.1242/dev.068601 · Cited by 377
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Metadata
- Authors
- Kikuchi, K., Gupta, V., Wang, J., Holdway, J. E., Wills, A. A., Fang, Y., & Poss, K. D.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2011-07-15
- Volume
- 138
- Issue
- 14
- Pages
- 2895-2902
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1985422522
- Cited by
- 298
- References
- 2
- FWCI
- 8.58
- Type
- journal article
- Language
- en
- Open access
- green
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- Kikuchi, K., Gupta, V., Wang, J., Holdway, J. E., Wills, A. A., Fang, Y., & Poss, K. D. (2011). tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration. Development. https://doi.org/10.1242/dev.067041
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