The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Epicardial FSTL1 reconstitution regenerates the adult mammalian heart
Open accessAbstract
The elucidation of factors that activate the regeneration of the adult mammalian heart is of major scientific and therapeutic importance. Here we found that epicardial cells contain a potent cardiogenic activity identified as follistatin-like 1 (Fstl1). Epicardial Fstl1 declines following myocardial infarction and is replaced by myocardial expression. Myocardial Fstl1 does not promote regeneration, either basally or upon transgenic overexpression. Application of the human Fstl1 protein (FSTL1) via an epicardial patch stimulates cell cycle entry and division of pre-existing cardiomyocytes, improving cardiac function and survival in mouse and swine models of myocardial infarction. The data suggest that the loss of epicardial FSTL1 is a maladaptive response to injury, and that its restoration would be an effective way to reverse myocardial death and remodelling following myocardial infarction in humans.
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Cites
Visualizing Spatiotemporal Dynamics of Multicellular Cell-Cycle Progression
Sakaue-Sawano, A., Kurokawa, H., Morimura, T., Hanyu, A., Hama, H., Osawa, H., Kashiwagi, S., Fukami, K., Miyata, T., Miyoshi, H., et al. (2008) · Cell · doi:10.1016/j.cell.2007.12.033 · Cited by 2,173
Cardiac progenitor cells from adult myocardium: Homing, differentiation, and fusion after infarction
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Self-citationMammalian heart renewal by pre-existing cardiomyocytes
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Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation
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Neuregulin1/ErbB4 Signaling Induces Cardiomyocyte Proliferation and Repair of Heart Injury
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A myocardial lineage derives from Tbx18 epicardial cells
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Adult mouse epicardium modulates myocardial injury by secreting paracrine factors
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Cited by
Sano, S., Oshima, K., Wang, Y., MacLauchlan, S., Katanasaka, Y., Sano, M., Zuriaga, M. A., Yoshiyama, M., Goukassian, D., Cooper, M. A., et al. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.12.037 · Cited by 699
Self-citationCardiomyocyte Regeneration: A Consensus Statement
Eschenhagen, T., Bolli, R., Braun, T., Field, L. J., Fleischmann, B. K., Frisén, J., Giacca, M., Hare, J. M., Houser, S., Lee, R. T., et al. (2017) · Circulation · doi:10.1161/circulationaha.117.029343 · Cited by 499
Self-citationLiu, B., Lee, B. W., Nakanishi, K., Villasante, A., Williamson, R., Metz, J., Kim, J., Kanai, M., Bi, L., Brown, K., et al. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0229-7 · Cited by 371
Muscle as a paracrine and endocrine organ
Giudice, J., & Taylor, J. M. (2017) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2017.05.005 · Cited by 331
Cahill, T. J., Choudhury, R. P., & Riley, P. R. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.106 · Cited by 312
Metadata
- Authors
- Wei, K., Serpooshan, V., Hurtado, C., Diez-Cuñado, M., Zhao, M., Maruyama, S., Zhu, W., Fajardo, G., Noseda, M., Nakamura, K., Tian, X., Liu, Q., Wang, A., Matsuura, Y., Bushway, P., Cai, W., Savchenko, A., Mahmoudi, M., Schneider, M. D., van den Hoff, M. J. B., Butte, M. J., Yang, P. C., Walsh, K., Zhou, B., Bernstein, D., Mercola, M., & Ruiz-Lozano, P.
- Venue
- Nature
- Published
- 2015-09
- Volume
- 525
- Issue
- 7570
- Pages
- 479-485
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2157671340
- Cited by
- 489
- References
- 37
- FWCI
- 19.43
- Type
- journal article
- Language
- en
- Open access
- green
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- Wei, K., Serpooshan, V., Hurtado, C., Diez-Cuñado, M., Zhao, M., Maruyama, S., Zhu, W., Fajardo, G., Noseda, M., Nakamura, K., Tian, X., Liu, Q., Wang, A., Matsuura, Y., Bushway, P., Cai, W., Savchenko, A., Mahmoudi, M., Schneider, M. D., . . . Ruiz-Lozano, P. (2015). Epicardial FSTL1 reconstitution regenerates the adult mammalian heart. Nature. https://doi.org/10.1038/nature15372
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
