The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells
Open accessAbstract
Notch signaling is known to regulate the proliferation and differentiation of intestinal stem and progenitor cells; however, direct cellular targets and specific functions of Notch signals had not been identified. We show here in mice that Notch directly targets the crypt base columnar (CBC) cell to maintain stem cell activity. Notch inhibition induced rapid CBC cell loss, with reduced proliferation, apoptotic cell death and reduced efficiency of organoid initiation. Furthermore, expression of the CBC stem cell-specific marker Olfm4 was directly dependent on Notch signaling, with transcription activated through RBP-Jκ binding sites in the promoter. Notch inhibition also led to precocious differentiation of epithelial progenitors into secretory cell types, including large numbers of cells that expressed both Paneth and goblet cell markers. Analysis of Notch function in Atoh1-deficient intestine demonstrated that the cellular changes were dependent on Atoh1, whereas Notch regulation of Olfm4 gene expression was Atoh1 independent. Our findings suggest that Notch targets distinct progenitor cell populations to maintain adult intestinal stem cells and to regulate cell fate choice to control epithelial cell homeostasis.
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Cites
Identification of stem cells in small intestine and colon by marker gene Lgr5
Barker, N., van Es, J. H., Kuipers, J., Kujala, P., van den Born, M., Cozijnsen, M., Haegebarth, A., Korving, J., Begthel, H., Peters, P. J., et al. (2007) · Nature · doi:10.1038/nature06196 · Cited by 5,687
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
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Control of endodermal endocrine development by Hes-1
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Canonical Wnt signals are essential for homeostasis of the intestinal epithelium
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Notch signals control the fate of immature progenitor cells in the intestine
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Requirement of Math1 for Secretory Cell Lineage Commitment in the Mouse Intestine
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Notch signaling controls multiple steps of pancreatic differentiation
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Cited by
Growing Self-Organizing Mini-Guts from a Single Intestinal Stem Cell: Mechanism and Applications
Sato, T., & Clevers, H. (2013) · Science · doi:10.1126/science.1234852 · Cited by 1,170
Martini, E., Krug, S. M., Siegmund, B., Neurath, M. F., & Becker, C. (2017) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2017.03.007 · Cited by 668
Wang, Y., Gunasekara, D. B., Reed, M. I., DiSalvo, M., Bultman, S. J., Sims, C. E., Magness, S. T., & Allbritton, N. L. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.03.005 · Cited by 373
Self-citationKetone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet
Cheng, C.-W., Biton, M., Haber, A. L., Gunduz, N., Eng, G., Gaynor, L. T., Tripathi, S., Calibasi-Kocal, G., Rickelt, S., Butty, V. L., et al. (2019) · Cell · doi:10.1016/j.cell.2019.07.048 · Cited by 373
Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche
Nusse, Y. M., Savage, A. K., Marangoni, P., Rosendahl-Huber, A. K. M., Landman, T. A., de Sauvage, F. J., Locksley, R. M., & Klein, O. D. (2018) · Nature · doi:10.1038/s41586-018-0257-1 · Cited by 341
Metadata
- Authors
- VanDussen, K. L., Carulli, A. J., Keeley, T. M., Patel, S. R., Puthoff, B. J., Magness, S. T., Tran, I. T., Maillard, I., Siebel, C., Kolterud, Å., Grosse, A. S., Gumucio, D. L., Ernst, S. A., Tsai, Y.-H., Dempsey, P. J., & Samuelson, L. C.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2012-02-01
- Volume
- 139
- Issue
- 3
- Pages
- 488-497
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2111214065
- Cited by
- 578
- References
- 62
- FWCI
- 8.46
- Type
- journal article
- Language
- en
- Open access
- green
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- VanDussen, K. L., Carulli, A. J., Keeley, T. M., Patel, S. R., Puthoff, B. J., Magness, S. T., Tran, I. T., Maillard, I., Siebel, C., Kolterud, Å., Grosse, A. S., Gumucio, D. L., Ernst, S. A., Tsai, Y.-H., Dempsey, P. J., & Samuelson, L. C. (2012). Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells. Development. https://doi.org/10.1242/dev.070763
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
