The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Dynamic responses of endothelial cells to changes in blood flow during vascular remodeling of the mouse yolk sac
Open accessAbstract
Despite extensive work showing the importance of blood flow in angiogenesis and vessel remodeling, very little is known about how changes in vessel diameter are orchestrated at the cellular level in response to mechanical forces. To define the cellular changes necessary for remodeling, we performed live confocal imaging of cultured mouse embryos during vessel remodeling. Our data revealed that vessel diameter increase occurs via two distinct processes that are dependent on normal blood flow: vessel fusions and directed endothelial cell migrations. Vessel fusions resulted in a rapid change in vessel diameter and were restricted to regions that experience the highest flow near the vitelline artery and vein. Directed cell migrations induced by blood flow resulted in the recruitment of endothelial cells to larger vessels from smaller capillaries and were observed in larger artery segments as they expanded. The dynamic and specific endothelial cell behaviors captured in this study reveal how sensitive endothelial cells are to changes in blood flow and how such responses drive vascular remodeling.
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Chiu, J.-J., & Chien, S. (2011) · Physiological Reviews · doi:10.1152/physrev.00047.2009 · Cited by 2,280
Interstitial flow influences direction of tumor cell migration through competing mechanisms
Polacheck, W. J., Charest, J. L., & Kamm, R. D. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103581108 · Cited by 509
Fluid forces control endothelial sprouting
Song, J. W., & Munn, L. L. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105316108 · Cited by 498
Migration dynamics of breast cancer cells in a tunable 3D interstitial flow chamber
Haessler, U., Teo, J. C. M., Foretay, D., Renaud, P., & Swartz, M. A. (2012) · Integrative Biology · doi:10.1039/c1ib00128k · Cited by 176
The Effects of Hemodynamic Force on Embryonic Development
CULVER, J. C., & DICKINSON, M. E. (2010) · Microcirculation · doi:10.1111/j.1549-8719.2010.00025.x · Cited by 173
Self-citation
Cited by
Mechanisms of Vessel Pruning and Regression
Korn, C., & Augustin, H. G. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.06.004 · Cited by 297
Dynamic Endothelial Cell Rearrangements Drive Developmental Vessel Regression
Franco, C. A., Jones, M. L., Bernabeu, M. O., Geudens, I., Mathivet, T., Rosa, A., Lopes, F. M., Lima, A. P., Ragab, A., Collins, R. T., et al. (2015) · PLOS Biology · doi:10.1371/journal.pbio.1002125 · Cited by 295
Primary cilia sensitize endothelial cells to BMP and prevent excessive vascular regression
Vion, A.-C., Alt, S., Klaus-Bergmann, A., Szymborska, A., Zheng, T., Perovic, T., Hammoutene, A., Oliveira, M. B., Bartels-Klein, E., Hollfinger, I., et al. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201706151 · Cited by 113
Metadata
- Authors
- Udan, R. S., Vadakkan, T. J., & Dickinson, M. E.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2013-10-01
- Volume
- 140
- Issue
- 19
- Pages
- 4041-4050
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2156927248
- Cited by
- 161
- References
- 5
- FWCI
- 5.38
- Type
- journal article
- Language
- en
- Open access
- green
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- Udan, R. S., Vadakkan, T. J., & Dickinson, M. E. (2013). Dynamic responses of endothelial cells to changes in blood flow during vascular remodeling of the mouse yolk sac. Development. https://doi.org/10.1242/dev.096255
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