The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Dynamic Endothelial Cell Rearrangements Drive Developmental Vessel Regression
Open accessAbstract
Patterning of functional blood vessel networks is achieved by pruning of superfluous connections. The cellular and molecular principles of vessel regression are poorly understood. Here we show that regression is mediated by dynamic and polarized migration of endothelial cells, representing anastomosis in reverse. Establishing and analyzing the first axial polarity map of all endothelial cells in a remodeling vascular network, we propose that balanced movement of cells maintains the primitive plexus under low shear conditions in a metastable dynamic state. We predict that flow-induced polarized migration of endothelial cells breaks symmetry and leads to stabilization of high flow/shear segments and regression of adjacent low flow/shear segments.
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Cites
Angiogenesis in life, disease and medicine
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Basic and Therapeutic Aspects of Angiogenesis
Potente, M., Gerhardt, H., & Carmeliet, P. (2011) · Cell · doi:10.1016/j.cell.2011.08.039 · Cited by 2,771
Self-citationCollective cell migration in morphogenesis, regeneration and cancer
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In Vivo Imaging of Embryonic Vascular Development Using Transgenic Zebrafish
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Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting
Jakobsson, L., Franco, C. A., Bentley, K., Collins, R. T., Ponsioen, B., Aspalter, I. M., Rosewell, I., Busse, M., Thurston, G., Medvinsky, A., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2103 · Cited by 971
Self-citationFluid Shear Stress on Endothelial Cells Modulates Mechanical Tension across VE-Cadherin and PECAM-1
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Flow regulates arterial-venous differentiation in the chick embryo yolk sac
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WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature
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Disruption of acvrl1 increases endothelial cell number in zebrafish cranial vessels
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Cited by
Vascular heterogeneity and specialization in development and disease
Potente, M., & Mäkinen, T. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.36 · Cited by 653
Vascular endothelial cell development and diversity
Trimm, E., & Red-Horse, K. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00770-1 · Cited by 537
Vascular Tissue Engineering: Progress, Challenges, and Clinical Promise
Song, H.-H. G., Rumma, R. T., Ozaki, C. K., Edelman, E. R., & Chen, C. S. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.02.009 · Cited by 476
Diabetic retinopathy: hyperglycaemia, oxidative stress and beyond
Hammes, H.-P. (2018) · Diabetologia · doi:10.1007/s00125-017-4435-8 · Cited by 357
Interpericyte tunnelling nanotubes regulate neurovascular coupling
Alarcon-Martinez, L., Villafranca-Baughman, D., Quintero, H., Kacerovsky, J. B., Dotigny, F., Murai, K. K., Prat, A., Drapeau, P., & Di Polo, A. (2020) · Nature · doi:10.1038/s41586-020-2589-x · Cited by 312
Metadata
- Authors
- Franco, C. A., Jones, M. L., Bernabeu, M. O., Geudens, I., Mathivet, T., Rosa, A., Lopes, F. M., Lima, A. P., Ragab, A., Collins, R. T., Phng, L.-K., Coveney, P. V., & Gerhardt, H.
- Venue
- PLOS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2015-04-17
- Volume
- 13
- Issue
- 4
- Pages
- e1002125
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- OpenAlex
- W2049681345
- Cited by
- 295
- References
- 32
- FWCI
- 9.39
- Type
- journal article
- Language
- en
- Open access
- gold
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- Franco, C. A., Jones, M. L., Bernabeu, M. O., Geudens, I., Mathivet, T., Rosa, A., Lopes, F. M., Lima, A. P., Ragab, A., Collins, R. T., Phng, L.-K., Coveney, P. V., & Gerhardt, H. (2015). Dynamic Endothelial Cell Rearrangements Drive Developmental Vessel Regression. PLOS Biology. https://doi.org/10.1371/journal.pbio.1002125
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