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Cited by 342

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Embryonic expression pattern of TGF beta type-1 RNA suggests both paracrine and autocrine mechanisms of action

Lehnert, Sigrid A., Akhurst, Rosemary J.·1988·Development
DOI 10.1242/dev.104.2.263
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Abstract

The tissue distribution of TGF beta form 1 RNA within mouse embryos of 10·5 to 15·5 days gestational age was investigated using in situ hybridization. As predicted from the prevalence of TGF beta-1 protein in adult bone and platelets, the RNA is highly abundant in fetal bone and in fetal liver megakaryocytes. Our data also reveal previously undocumented sites of synthesis for TGF beta-1, namely epithelia overlying those mesenchymal tissues that are known to contain TGF beta protein as detected by immunohistochemical methods (Heine et al. 1987) and in the mesenchymal tissues of certain internal organs. From a combined knowledge of the distributions of the TGF beta polypeptide (Heine et al. 1987) and its mRNA, and a knowledge of the reported biological activities of TGF beta-1, we invoke both paracrine and autocrine mechanisms of action for this growth factor.

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Metadata

Authors
Lehnert, S. A., & Akhurst, R. J.
Venue
Development
Publisher
The Company of Biologists
Published
1988-10-01
Volume
104
Issue
2
Pages
263-273
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
DOI
10.1242/dev.104.2.263
OpenAlex
W1839414684
Cited by
342
References
40
FWCI
15.12
Type
journal article
Language
en
Open access
closed

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