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An assessment of the developmental potential of embryonic stem cells in the midgestation mouse embryo

Beddington, R. S. P., Robertson, E. J.·1989·Development

Abstract

Embryonic stem cells (ES) cells were injected into host blastocysts either in groups of 10–15 cells or as single cells in order to test their developmental potential in the developing embryo. The analysis of midgestation chimaeras, by electrophoretic separation of glucose phosphate isomerase (GPI) isozymes, showed that ES cells were capable of colonizing trophectoderm and primitive endoderm derivatives at a low frequency, as well as producing a high rate of chimaerism in tissues of the fetus and extraembryonlc mesoderm.

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Metadata

Authors
Beddington, R. S. P., & Robertson, E. J.
Venue
Development
Published
1989-04-01
Volume
105
Issue
4
Pages
733-737
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
OpenAlex
W1894129931
Cited by
593
References
0
FWCI
3.72
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: An assessment of the developmental potential of embryonic stem cells in the midgestation mouse embryo. https://app.cochat.ai/papers/10.1242/dev.105.4.733
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Beddington, R. S. P., & Robertson, E. J. (1989). An assessment of the developmental potential of embryonic stem cells in the midgestation mouse embryo. Development. https://doi.org/10.1242/dev.105.4.733

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.