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An assessment of the developmental potential of embryonic stem cells in the midgestation mouse embryo
Abstract
Embryonic stem cells (ES) cells were injected into host blastocysts either in groups of 10–15 cells or as single cells in order to test their developmental potential in the developing embryo. The analysis of midgestation chimaeras, by electrophoretic separation of glucose phosphate isomerase (GPI) isozymes, showed that ES cells were capable of colonizing trophectoderm and primitive endoderm derivatives at a low frequency, as well as producing a high rate of chimaerism in tissues of the fetus and extraembryonlc mesoderm.
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Metadata
- Authors
- Beddington, R. S. P., & Robertson, E. J.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1989-04-01
- Volume
- 105
- Issue
- 4
- Pages
- 733-737
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1894129931
- Cited by
- 593
- References
- 0
- FWCI
- 3.72
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.