The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Specific spatial and temporal distribution of retinoic acid receptor gamma transcripts during mouse embryogenesis
Abstract
Retinoic acid (RA), a putative morphogen in vertebrates, has profound effects on development during embryogenesis, chondrogenesis and differentiation of squamous epithelia. The distribution of the transcripts of the retinoic acid receptor gamma (RAR-γ) gene has been studied here by in situ hybridization during mouse development from days 6.5 to 15.5 post-coitum (p.c.). RAR-γ transcripts are detected as early as day 8 p.c. in the presomitic posterior region. Between days 9.5 and 11.5 p.c., the transcripts are uniformly distributed in the mesenchyme of the frontonasal region, pharyngeal arches, limb buds and sclerotomes. At day 12.5 p.c., RAR-γ transcripts are found in all precartilaginous mesenchymal condensations. From day 13.5 p.c., the transcripts are specifically localized in all cartilages and differentiating squamous keratinizing epithelia, irrespective of their embryological origin. RAR-γ transcripts are also found in the developing teeth and whisker follicles. The developmental pattern of expression of the RAR-γ gene suggests that RAR-γ plays a crucial role for transducing RA signals at the level of gene expression during morphogenesis, chondrogenesis and differentiation of squamous epithelia.
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Metadata
- Authors
- Ruberte, E., Dolle, P., Krust, A., Zelent, A., Morriss-Kay, G., & Chambon, P.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1990-02-01
- Volume
- 108
- Issue
- 2
- Pages
- 213-222
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1868208269
- Cited by
- 349
- References
- 36
- FWCI
- 17.42
- Type
- journal article
- Language
- en
- Open access
- closed
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