The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Enteroendocrine cells are generated from stem cells through a distinct progenitor in the adult Drosophila posterior midgut
Open accessAbstract
Functional mature cells are continually replenished by stem cells to maintain tissue homoeostasis. In the adult Drosophila posterior midgut, both terminally differentiated enterocyte (EC) and enteroendocrine (EE) cells are generated from an intestinal stem cell (ISC). However, it is not clear how the two differentiated cells are generated from the ISC. In this study, we found that only ECs are generated through the Su(H)GBE+ immature progenitor enteroblasts (EBs), whereas EEs are generated from ISCs through a distinct progenitor pre-EE by a novel lineage-tracing system. EEs can be generated from ISCs in three ways: an ISC becoming an EE, an ISC becoming a new ISC and an EE through asymmetric division, or an ISC becoming two EEs through symmetric division. We further identified that the transcriptional factor Prospero (Pros) regulates ISC commitment to EEs. Our data provide direct evidence that different differentiated cells are generated by different modes of stem cell lineage specification within the same tissues.
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Cites
Identification of stem cells in small intestine and colon by marker gene Lgr5
Barker, N., van Es, J. H., Kuipers, J., Kujala, P., van den Born, M., Cozijnsen, M., Haegebarth, A., Korving, J., Begthel, H., Peters, P. J., et al. (2007) · Nature · doi:10.1038/nature06196 · Cited by 5,687
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
Sato, T., van Es, J. H., Snippert, H. J., Stange, D. E., Vries, R. G., van den Born, M., Barker, N., Shroyer, N. F., van de Wetering, M., & Clevers, H. (2011) · Nature · doi:10.1038/nature09637 · Cited by 2,510
Intestinal label-retaining cells are secretory precursors expressing Lgr5
Buczacki, S. J. A., Zecchini, H. I., Nicholson, A. M., Russell, R., Vermeulen, L., Kemp, R., & Winton, D. J. (2013) · Nature · doi:10.1038/nature11965 · Cited by 761
Interconversion Between Intestinal Stem Cell Populations in Distinct Niches
Takeda, N., Jain, R., LeBoeuf, M. R., Wang, Q., Lu, M. M., & Epstein, J. A. (2011) · Science · doi:10.1126/science.1213214 · Cited by 742
Strategies for Homeostatic Stem Cell Self-Renewal in Adult Tissues
Simons, B. D., & Clevers, H. (2011) · Cell · doi:10.1016/j.cell.2011.05.033 · Cited by 489
Cited by
Anatomy and Physiology of the Digestive Tract of Drosophila melanogaster
Miguel-Aliaga, I., Jasper, H., & Lemaitre, B. (2018) · Genetics · doi:10.1534/genetics.118.300224 · Cited by 491
Intestinal Enteroendocrine Lineage Cells Possess Homeostatic and Injury-Inducible Stem Cell Activity
Yan, K. S., Gevaert, O., Zheng, G. X. Y., Anchang, B., Probert, C. S., Larkin, K. A., Davies, P. S., Cheng, Z.-F., Kaddis, J. S., Han, A., et al. (2017) · Cell Stem Cell · doi:10.1016/j.stem.2017.06.014 · Cited by 361
A cell atlas of the adult Drosophila midgut
Hung, R.-J., Hu, Y., Kirchner, R., Liu, Y., Xu, C., Comjean, A., Tattikota, S. G., Li, F., Song, W., Ho Sui, S., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1916820117 · Cited by 282
Dutta, D., Dobson, A. J., Houtz, P. L., Gläßer, C., Revah, J., Korzelius, J., Patel, P. H., Edgar, B. A., & Buchon, N. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.06.009 · Cited by 254
Metadata
- Authors
- Zeng, X., & Hou, S. X.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2015-02-15
- Volume
- 142
- Issue
- 4
- Pages
- 644-653
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2126471829
- Cited by
- 236
- References
- 5
- FWCI
- 8.11
- Type
- journal article
- Language
- en
- Open access
- green
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- Zeng, X., & Hou, S. X. (2015). Enteroendocrine cells are generated from stem cells through a distinct progenitor in the adult Drosophila posterior midgut. Development. https://doi.org/10.1242/dev.113357
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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