JNK Signaling is necessary for a Wnt and stem cell dependent regeneration program

Tejada-Romero, Belen; Carter, Jean-Michel; Mihaylova, Yuliana; Neumann, Bjoern; Aboobaker, A. Aziz

doi:10.1242/dev.115139

Cited by 27Planarian Biology and ElectrostimulationDevelopmental Biology and Gene RegulationMarine Invertebrate Physiology and Ecology

JNK Signaling is necessary for a Wnt and stem cell dependent regeneration program

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Tejada-Romero, Belen, Carter, Jean-Michel, Mihaylova, Yuliana, Neumann, Bjoern, Aboobaker, A. Aziz·2015·Development

DOI 10.1242/dev.115139PMC PMC4510858

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Abstract

Regeneration involves the integration of new and old tissues in the context of an adult life history. It is clear that the core conserved signaling pathways that orchestrate development also play central roles in regeneration and further study of conserved signaling pathway is required. Here we have studied the role of the conserved JNK signaling cascade during planarian regeneration. Abrogation of JNK signaling by RNAi or pharmacological inhibition blocks posterior regeneration and animals fail to express posterior markers. While early injury induced expression of polarity markers is unaffected, the later stem cell dependent phase of posterior Wnt expression is not established. This defect can be rescued by over-activation of the Hh or Wnt signaling pathway to promote posterior Wnt activity. Together our data suggest JNK signaling is required to establish stem cell dependent Wnt expression after posterior injury. Given that in vertebrates Jun has been previously shown to be required for the expression of Wnt and Wnt target genes, we propose that this interaction may be conserved and is an instructive part of planarian posterior regeneration.

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In regenerating animals, pole expression of wnt1 is impaired in irradiated animals or after inhibition of several transcription factors Djislet, junli, and pitx.
“By contrast, in regenerating animals, pole expression of wnt1 is impaired in irradiated animals or after inhibition of several transcription factors Djislet, junli, and pitx [10, 30–32, 40].”
From STRIPAK limits stem cell differentiation of a WNT signaling center to control planarian axis scaling (2020) · cites this paper as [40]

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Authors: Tejada-Romero, B., Carter, J.-M., Mihaylova, Y., Neumann, B., & Aboobaker, A. A.
Affiliations: Department of Zoology, Tinbergen Building, South Parks Road, University of Oxford, OX1 3PS Oxford, United Kingdom
University of Oxford (GB)
Corresponding author: Aboobaker, A. Aziz
ORCID: Carter, Jean-Michel
Mihaylova, Yuliana
Aboobaker, A. Aziz
Venue: Development
Publisher: The Company of Biologists
Published: 2015-01-01
Volume: 142
Issue: 14
Pages: 2413-24
ISSN: 0950-1991 (ISSN-L)
1477-9129
DOI: 10.1242/dev.115139
PMC: PMC4510858
OpenAlex: W1822595349
Cited by: 27
References: 71
Citations by year: 2025: 1 · 2024: 1 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 5 · 2018: 3 · 2017: 3 · 2016: 6
FWCI: 1.74
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Development (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Medical Research Council (MR/M000133/1)
Biotechnology and Biological Sciences Research Council (BB/K007564/1)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Planarian Biology and Electrostimulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Physical Sciences › Earth and Planetary Sciences › Paleontology › Marine Invertebrate Physiology and Ecology
Keywords: JNK signaling, planarian regeneration, posterior regeneration, Wnt signaling, stem cells, Hedgehog signaling, c-Jun, tissue regeneration, conserved signaling pathways
MeSH terms: Animals, Cell Differentiation, Gene Expression Regulation, Phenotype, Planarians, Regeneration, Stem Cells, Signal Transduction, Genome, Gene Expression Regulation, Developmental, Body Patterning, Gene Expression Profiling, MAP Kinase Signaling System, RNA Interference, MAP Kinase Kinase 4, Wnt Proteins

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JNK Signaling is necessary for a Wnt and stem cell dependent regeneration program

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