The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Induction of vasculogenesis and hematopoiesis in vitro
Abstract
Despite a large number of investigations of embryonic vascular development, in particular in avian embryos, the conditions under which the endothelial and hematopoietic cell lineages emerge remain unknown. As we demonstrate here, both endothelial and hematopoietic cells can be induced by treatment of dissociated quail epiblast with fibroblast growth factors in vitro. These cells aggregate in characteristic blood islands. In long-term culture, the induced endothelial cells gave rise to vascular structures in vitro, i.e. vasculogenesis. No induction was observed in the absence of fibroblast growth factors, and other growth factors like TGF-β, TGF-α and EGF were not capable of inducing blood island formation. Thus, the dissociated quail epiblast provides a remarkably simple test system to investigate cell lineage diversification in higher vertebrates.
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Defective Angiogenesis in Mice Lacking Endoglin
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Neuronal defects and delayed wound healing in mice lacking fibroblast growth factor 2
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Gunsilius, E., Duba, H.-C., Petzer, A. L., Kahler, C. M., Grunewald, K., Stockhammer, G., Gabl, C., Dirnhofer, S., Clausen, J., & Gastl, G. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02241-8 · Cited by 337
Metadata
- Authors
- Flamme, I., & Risau, W.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1992-10-01
- Volume
- 116
- Issue
- 2
- Pages
- 435-439
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2144789700
- Cited by
- 339
- References
- 18
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- closed
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