The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The protein product of the zebrafish homologue of the mouse T gene is expressed in nuclei of the germ ring and the notochord of the early embryo
Abstract
Embryos mutant for the T gene, in mice, make insufficient mesoderm and fail to develop a notochord. We report the cloning and sequencing of the T gene in the zebrafish (Brachydanio rerio) and show the nuclear localization of the protein product. Both RNA and protein are found in cells of the germ ring, including enveloping layer cells, prior to and during gastrulation of zebrafish embryos. Nuclei of the yolk syncytial layer do not express Zf-T. High levels of expression are maintained throughout early development in the notochord, while in paraxial mesoderm cells the gene is turned off during gastrulation. Exposure of animal cap cells to activinA induces Zf-T expression, as does transplantation into the germ ring.
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Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
SEGREGATION ANALYSES AND GENE-CENTROMERE DISTANCES IN ZEBRAFISH
Streisinger, G., Singer, F., Walker, C., Knauber, D., & Dower, N. (1986) · Genetics · doi:10.1093/genetics/112.2.311 · Cited by 245
Cited by
Stages of embryonic development of the zebrafish
Kimmel, C. B., Ballard, W. W., Kimmel, S. R., Ullmann, B., & Schilling, T. F. (1995) · Developmental Dynamics · doi:10.1002/aja.1002030302 · Cited by 12,037
Thisse, C., Thisse, B., Schilling, T. F., & Postlethwait, J. H. (1993) · Development · doi:10.1242/dev.119.4.1203 · Cited by 877
A homeobox gene essential for zebrafish notochord development
Talbot, W. S., Trevarrow, B., Halpern, M. E., Melby, A. E., Farr, G., Postlethwait, J. H., Jowett, T., Kimmel, C. B., & Kimelman, D. (1995) · Nature · doi:10.1038/378150a0 · Cited by 465
Mullins, M. C., Hammerschmidt, M., Kane, D. A., Odenthal, J., Brand, M., Eeden, F. J. M. V., Furutani-Seiki, M., Granato, M., Haffter, P., Heisenberg, C.-P., et al. (1996) · Development · doi:10.1242/dev.123.1.81 · Cited by 420
Self-citationMyelopoiesis in the zebrafish, Danio rerio
Bennett, C. M., Kanki, J. P., Rhodes, J., Liu, T. X., Paw, B. H., Kieran, M. W., Langenau, D. M., Delahaye-Brown, A., Zon, L. I., Fleming, M. D., et al. (2001) · Blood · doi:10.1182/blood.v98.3.643 · Cited by 391
Metadata
- Authors
- Schulte-Merker, S., Ho, R. K., Herrmann, B. G., & NÜsslein-Volhard, C.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1992-12-01
- Volume
- 116
- Issue
- 4
- Pages
- 1021-1032
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2111479560
- Cited by
- 644
- References
- 2
- FWCI
- 11.07
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The protein product of the zebrafish homologue of the mouse T gene is expressed in nuclei of the germ ring and the notochord of the early embryo. https://app.cochat.ai/papers/10.1242/dev.116.4.1021
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- Schulte-Merker, S., Ho, R. K., Herrmann, B. G., & NÜsslein-Volhard, C. (1992). The protein product of the zebrafish homologue of the mouse T gene is expressed in nuclei of the germ ring and the notochord of the early embryo. Development. https://doi.org/10.1242/dev.116.4.1021
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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