The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Lithium perturbation and goosecoid expression identify a dorsal specification pathway in the pregastrula zebrafish
Abstract
The zebrafish dorsoventral axis can first be distin-guished at gastrulation, upon formation of the embry-onic shield, the site of the organizer. We have asked whether the shield is specified before gastrulation. First, we show that brief exposure of premidblastula embryos to lithium, which is known to shut down the phospho-inositol signaling pathway, produces excessive shield formation and extreme hyper-dorsal development. Second, we show that the zebrafish goosecoid homeobox gene is activated at or just after the midblastula in a localized domain of cells that subsequently populate the most anterior region of the incipient shield and axial hypoblast. goosecoid expression is elevated and radialized by early lithium treatment, suggesting that goosec -oid plays a role in establishing the organizer and shield. Our results demonstrate that the zebrafish dorsal axis is signaled by a pathway initiated in the cleavage-stage embryo. Furthermore, they provide novel insights into anterior morphogenesis.
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Citations
Cites
Organization of hindbrain segments in the zebrafish embryo
Trevarrow, B., Marks, D. L., & Kimmel, C. B. (1990) · Neuron · doi:10.1016/0896-6273(90)90194-k · Cited by 506
How embryos work: a comparative view of diverse modes of cell fate specification
Davidson, E. H. (1990) · Development · doi:10.1242/dev.108.3.365 · Cited by 267
Cited by
Stages of embryonic development of the zebrafish
Kimmel, C. B., Ballard, W. W., Kimmel, S. R., Ullmann, B., & Schilling, T. F. (1995) · Developmental Dynamics · doi:10.1002/aja.1002030302 · Cited by 12,037
Spatial reconstruction of single-cell gene expression data
Satija, R., Farrell, J. A., Gennert, D., Schier, A. F., & Regev, A. (2015) · Nature Biotechnology · doi:10.1038/nbt.3192 · Cited by 7,055
A homeobox gene essential for zebrafish notochord development
Talbot, W. S., Trevarrow, B., Halpern, M. E., Melby, A. E., Farr, G., Postlethwait, J. H., Jowett, T., Kimmel, C. B., & Kimelman, D. (1995) · Nature · doi:10.1038/378150a0 · Cited by 465
Mullins, M. C., Hammerschmidt, M., Kane, D. A., Odenthal, J., Brand, M., Eeden, F. J. M. V., Furutani-Seiki, M., Granato, M., Haffter, P., Heisenberg, C.-P., et al. (1996) · Development · doi:10.1242/dev.123.1.81 · Cited by 420
Schier, A. F., Neuhauss, S. C. F., Helde, K. A., Talbot, W. S., & Driever, W. (1997) · Development · doi:10.1242/dev.124.2.327 · Cited by 359
Metadata
- Authors
- Stachel, S. E., Grunwald, D. J., & Myers, P. Z.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1993-04-01
- Volume
- 117
- Issue
- 4
- Pages
- 1261-1274
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2116428404
- Cited by
- 454
- References
- 2
- FWCI
- 7.87
- Type
- journal article
- Language
- en
- Open access
- closed
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