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Cited by 454

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

Lithium perturbation and goosecoid expression identify a dorsal specification pathway in the pregastrula zebrafish

Stachel, Scott E., Grunwald, David J., Myers, Paul Z.·1993·Development
DOI 10.1242/dev.117.4.1261
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Abstract

The zebrafish dorsoventral axis can first be distin-guished at gastrulation, upon formation of the embry-onic shield, the site of the organizer. We have asked whether the shield is specified before gastrulation. First, we show that brief exposure of premidblastula embryos to lithium, which is known to shut down the phospho-inositol signaling pathway, produces excessive shield formation and extreme hyper-dorsal development. Second, we show that the zebrafish goosecoid homeobox gene is activated at or just after the midblastula in a localized domain of cells that subsequently populate the most anterior region of the incipient shield and axial hypoblast. goosecoid expression is elevated and radialized by early lithium treatment, suggesting that goosec -oid plays a role in establishing the organizer and shield. Our results demonstrate that the zebrafish dorsal axis is signaled by a pathway initiated in the cleavage-stage embryo. Furthermore, they provide novel insights into anterior morphogenesis.

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Metadata

Authors
Stachel, S. E., Grunwald, D. J., & Myers, P. Z.
Venue
Development
Publisher
The Company of Biologists
Published
1993-04-01
Volume
117
Issue
4
Pages
1261-1274
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
DOI
10.1242/dev.117.4.1261
OpenAlex
W2116428404
Cited by
454
References
48
FWCI
7.87
Type
journal article
Language
en
Open access
closed

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