The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Modeling mouse and human development using organoid cultures
Abstract
In vitro three-dimensional (3D) cultures are emerging as novel systems with which to study tissue development, organogenesis and stem cell behavior ex vivo. When grown in a 3D environment, embryonic stem cells (ESCs) self-organize into organoids and acquire the right tissue patterning to develop into several endoderm- and ectoderm-derived tissues, mimicking their in vivo counterparts. Tissue-resident adult stem cells (AdSCs) also form organoids when grown in 3D and can be propagated in vitro for long periods of time. In this Review, we discuss recent advances in the generation of pluripotent stem cell- and AdSC-derived organoids, highlighting their potential for enhancing our understanding of human development. We will also explore how this new culture system allows disease modeling and gene repair for a personalized regenerative medicine approach.
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Cites
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BackgroundProspective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients
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Self-citationSelf-organizing optic-cup morphogenesis in three-dimensional culture
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Cited by
Human organoids: model systems for human biology and medicine
Kim, J., Koo, B.-K., & Knoblich, J. A. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0259-3 · Cited by 2,187
Self-citationInduced pluripotent stem cell technology: a decade of progress.
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Human primary liver cancer–derived organoid cultures for disease modeling and drug screening
Broutier, L., Mastrogiovanni, G., Verstegen, M. M., Francies, H. E., Gavarró, L. M., Bradshaw, C. R., Allen, G. E., Arnes-Benito, R., Sidorova, O., Gaspersz, M. P., et al. (2017) · Nature Medicine · doi:10.1038/nm.4438 · Cited by 1,471
“Thus retinal, cerebral, kidney, intestinal and 71 stomach organoids (among others) have already been generated from pluripotent stem cells 72 for the study of human development and disease ex vivo [15].”
InfluentialSelf-citationZhao, Z., Chen, X., Dowbaj, A. M., Sljukic, A., Bratlie, K., Lin, L., Fong, E. L. S., Balachander, G. M., Chen, Z., Soragni, A., et al. (2022) · Nature Reviews Methods Primers · doi:10.1038/s43586-022-00174-y · Cited by 1,082
Self-citationThree-Dimensional Cell Cultures in Drug Discovery and Development
Fang, Y., & Eglen, R. M. (2017) · SLAS Discovery · doi:10.1177/1087057117696795 · Cited by 849
Metadata
- Authors
- Huch, M., & Koo, B.-K.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2015-09-15
- Volume
- 142
- Issue
- 18
- Pages
- 3113-3125
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2174254214
- Cited by
- 539
- References
- 28
- FWCI
- 17.11
- Type
- journal article
- Language
- en
- Open access
- closed
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