The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Programmed cell death in the Drosophila CNS is ecdysone-regulated and coupled with a specific ecdysone receptor isoform
Abstract
At adult emergence, the ventral CNS of Drosophila shows a group of approximately 300 neurons, which are unique in that they express 10-fold higher levels of the A isoform of the ecdysone receptor (EcR-A) than do other central neurons. This expression pattern is established early in metamorphosis and persists throughout the remainder of the pupal stage. Although these cells represent a heterogeneous group of neurons, they all share the same fate of undergoing rapid degeneration after the adult emerges from the pupal case. One prerequisite for this death is the decline of ecdysteroids at the end of metamorphosis. Treatment of flies with 20hydroxyecdysone blocks the death of the cells, but only if given at least 3 hours before the normal time of degeneration. The correlation of a unique pattern of receptor isoform expression with a particular steroid-regulated fate suggests that variations in the pattern of receptor isoform expression may serve as important switches during development.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Gene regulation by steroid hormones
Beato, M. (1989) · Cell · doi:10.1016/0092-8674(89)90237-7 · Cited by 3,383
Temporal control of puffing activity in polytene chromosomes
Ashburner, M., Chihara, C., Meltzer, P., & Richards, G. (1974) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1974.038.01.070 · Cited by 641
Ikeda, K., & Koenig, J. H. (1988) · Journal of Comparative Neurology · doi:10.1002/cne.902730312 · Cited by 92
Cited by
The head involution defective gene of Drosophila melanogaster functions in programmed cell death.
Grether, M. E., Abrams, J. M., Agapite, J., White, K., & Steller, H. (1995) · Genes & Development · doi:10.1101/gad.9.14.1694 · Cited by 699
Ecdysone receptors and their biological actions
Riddiford, L. M., Cherbas, P., & Truman, J. W. (2000) · Vitamins & Hormones · doi:10.1016/s0083-6729(00)60016-x · Cited by 605
Self-citationFlies on steroids — Drosophila metamorphosis and the mechanisms of steroid hormone action
Thummel, C. S. (1996) · Trends in Genetics · doi:10.1016/0168-9525(96)10032-9 · Cited by 489
Steroid regulated programmed cell death during Drosophila metamorphosis
Jiang, C., Baehrecke, E. H., & Thummel, C. S. (1997) · Development · doi:10.1242/dev.124.22.4673 · Cited by 391
Hormones and the physiological architecture of life history evolution
Finch, C. E., & Rose, M. R. (1995) · The Quarterly Review of Biology · doi:10.1086/418864 · Cited by 376
Metadata
- Authors
- Robinow, S., Talbot, W. S., Hogness, D. S., & Truman, J. W.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1993-12-01
- Volume
- 119
- Issue
- 4
- Pages
- 1251-1259
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2131840309
- Cited by
- 219
- References
- 3
- FWCI
- 3.67
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Programmed cell death in the Drosophila CNS is ecdysone-regulated and coupled with a specific ecdysone receptor isoform. https://app.cochat.ai/papers/10.1242/dev.119.4.1251
- The paper
- Robinow, S., Talbot, W. S., Hogness, D. S., & Truman, J. W. (1993). Programmed cell death in the Drosophila CNS is ecdysone-regulated and coupled with a specific ecdysone receptor isoform. Development. https://doi.org/10.1242/dev.119.4.1251
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
