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lag-2 may encode a signaling ligand for the GLP-1 and LIN-12 receptors of C. elegans
Abstract
The C. elegans lag-2 gene is required for several cell-cell interactions that rely on the receptors GLP-1 and LIN-12. In this paper, we report that lag-2 encodes a putative membrane protein with sequence similarity to Drosophila Delta, a proposed ligand for the Notch receptor. Furthermore, we show that the lag-2 promoter drives expression of a reporter protein in the signaling distal tip cell (DTC) of the DTC/germline interaction. By in situ hybridization, we have found that endogenous lag-2 mRNA is present in the DTC but not the germ line. One fusion protein, called LAG-2::β-gal(intra), rescues a lag-2 null mutant and can be detected in both DTC and germ line. Taking these results together, we propose that lag-2 may encode a signaling ligand for GLP-1/LIN-12 and that the entire LAG-2 protein may be taken up into the receiving cell during induction by GLP-1 and lateral signaling by LIN-12.
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Cited by
Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia
Joutel, A., Corpechot, C., Ducros, A., Vahedi, K., Chabriat, H., Mouton, P., Alamowitch, S., Domenga, V., Cécillion, M., Maréchal, E., et al. (1996) · Nature · doi:10.1038/383707a0 · Cited by 2,068
Artavanis-Tsakonas, S., Matsuno, K., & Fortini, M. E. (1995) · Science · doi:10.1126/science.7716513 · Cited by 1,303
Notch signaling: control of cell communication and cell fate
Lai, E. C. (2004) · Development · doi:10.1242/dev.01074 · Cited by 1,050
Regulatory Mechanisms in Stem Cell Biology
Morrison, S. J., Shah, N. M., & Anderson, D. J. (1997) · Cell · doi:10.1016/s0092-8674(00)81867-x · Cited by 1,043
Expression of a Delta homologue in prospective neurons in the chick
Henrique, D., Adam, J., Myat, A., Chitnis, A., Lewis, J., & Ish-Horowicz, D. (1995) · Nature · doi:10.1038/375787a0 · Cited by 992
Chitnis, A., Henrique, D., Lewis, J., Ish-Horowicz, D., & Kintner, C. (1995) · Nature · doi:10.1038/375761a0 · Cited by 675
Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene
Uyttendaele, H., Marazzi, G., Wu, G., Yan, Q., Sassoon, D., & Kitajewski, J. (1996) · Development · doi:10.1242/dev.122.7.2251 · Cited by 485
Hsieh, J. J.-D., Henkel, T., Salmon, P., Robey, E., Peterson, M. G., & Hayward, S. D. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.3.952 · Cited by 451
Canonical and Non-Canonical Notch Ligands
D’Souza, B., Meloty-Kapella, L., & Weinmaster, G. (2010) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(10)92003-6 · Cited by 362
Requirement for Dynamin during Notch Signaling inDrosophilaNeurogenesis
Seugnet, L., Simpson, P., & Haenlin, M. (1997) · Developmental Biology · doi:10.1006/dbio.1997.8723 · Cited by 263
Metadata
- Authors
- Henderson, S. T., Gao, D., Lambie, E. J., & Kimble, J.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1994-10-01
- Volume
- 120
- Issue
- 10
- Pages
- 2913-2924
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2164221181
- Cited by
- 388
- References
- 0
- FWCI
- 7.60
- Type
- journal article
- Language
- en
- Open access
- closed
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