The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
diaphanous is required for cytokinesis in Drosophila and shares domains of similarity with the products of the limb deformity gene
Abstract
We show that the Drosophila gene diaphanous is required for cytokinesis. Males homozygous for the dia1 mutation are sterile due to a defect in cytokinesis in the germline. Females trans-heterozygous for dia1 and a deficiency are sterile and lay eggs with defective eggshells; failure of cytokinesis is observed in the follicle cell layer. Null alleles are lethal. Death occurs at the onset of pupation due to the absence of imaginal discs. Mitotic figures in larval neuroblasts were found to be polyploid, apparently due to a defect in cytokinesis. The predicted 123×103Mr protein contains two domains shared by the formin proteins, encoded by the limb deformity gene in the mouse. These formin homology domains, which we have termed FH1 and FH2, are also found in Bni1p, the product of a Saccharomyces cerevisiae gene required for normal cytokinesis in diploid yeast cells.
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Cites
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Cited by
Rho GTPases and their effector proteins
BISHOP, A. L., & HALL, A. (2000) · Biochemical Journal · doi:10.1042/bj3480241 · Cited by 2,575
Cell migration: Rho GTPases lead the way
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Alberts, A. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006205200 · Cited by 329
Imamura, H. (1997) · The EMBO Journal · doi:10.1093/emboj/16.10.2745 · Cited by 310
Metadata
- Authors
- Castrillon, D. H., & Wasserman, S. A.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1994-12-01
- Volume
- 120
- Issue
- 12
- Pages
- 3367-3377
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2122087650
- Cited by
- 420
- References
- 37
- FWCI
- 5.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- Castrillon, D. H., & Wasserman, S. A. (1994). diaphanous is required for cytokinesis in Drosophila and shares domains of similarity with the products of the limb deformity gene. Development. https://doi.org/10.1242/dev.120.12.3367
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
