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Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site
Abstract
The Src homology 3 (SH3) region is a small protein domain present in a very large group of proteins, including cytoskeletal elements and signaling proteins. It is believed that SH3 domains serve as modules that mediate protein-protein associations and, along with Src homology 2 (SH2) domains, regulate cytoplasmic signaling. The SH3 binding sites of two SH3 binding proteins were localized to a nine- or ten-amino acid stretch very rich in proline residues. Similar SH3 binding motifs exist in the formins, proteins that function in pattern formation in embryonic limbs of the mouse, and one subtype of the muscarinic acetylcholine receptor. Identification of the SH3 binding site provides a basis for understanding the interaction between the SH3 domains and their targets.
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Cited by
Prolactin: structure, function, and regulation of secretion
Freeman, M. E., Kanyicska, B., Lerant, A., & Nagy, G. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.4.1523 · Cited by 2,457
Protein modules and signalling networks
Pawson, T. (1995) · Nature · doi:10.1038/373573a0 · Cited by 2,420
Rao, E., Weiss, B., Fukami, M., Rump, A., Niesler, B., Mertz, A., Muroya, K., Binder, G., Kirsch, S., Winkelmann, M., et al. (1997) · Nature Genetics · doi:10.1038/ng0597-54 · Cited by 943
Modular binding domains in signal transduction proteins
Cohen, G. B., Ren, R., & Baltimore, D. (1995) · Cell · doi:10.1016/0092-8674(95)90406-9 · Cited by 951
Self-citationC-type lectin receptors on dendritic cells and langerhans cells
Figdor, C. G., van Kooyk, Y., & Adema, G. J. (2002) · Nature Reviews Immunology · doi:10.1038/nri723 · Cited by 842
Metadata
- Authors
- Ren, R., Mayer, B. J., Cicchetti, P., & Baltimore, D.
- Venue
- Science
- Published
- 1993-02-19
- Volume
- 259
- Issue
- 5098
- Pages
- 1157-1161
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2085140159
- Cited by
- 1,191
- References
- 0
- FWCI
- 56.08
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ren, R., Mayer, B. J., Cicchetti, P., & Baltimore, D. (1993). Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site. Science. https://doi.org/10.1126/science.8438166
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