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Cited by 420

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

diaphanous is required for cytokinesis in Drosophila and shares domains of similarity with the products of the limb deformity gene

Castrillon, Diego H., Wasserman, Steven A.·1994·Development
DOI 10.1242/dev.120.12.3367
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Abstract

We show that the Drosophila gene diaphanous is required for cytokinesis. Males homozygous for the dia1 mutation are sterile due to a defect in cytokinesis in the germline. Females trans-heterozygous for dia1 and a deficiency are sterile and lay eggs with defective eggshells; failure of cytokinesis is observed in the follicle cell layer. Null alleles are lethal. Death occurs at the onset of pupation due to the absence of imaginal discs. Mitotic figures in larval neuroblasts were found to be polyploid, apparently due to a defect in cytokinesis. The predicted 123×103Mr protein contains two domains shared by the formin proteins, encoded by the limb deformity gene in the mouse. These formin homology domains, which we have termed FH1 and FH2, are also found in Bni1p, the product of a Saccharomyces cerevisiae gene required for normal cytokinesis in diploid yeast cells.

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Metadata

Authors
Castrillon, D. H., & Wasserman, S. A.
Venue
Development
Publisher
The Company of Biologists
Published
1994-12-01
Volume
120
Issue
12
Pages
3367-3377
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
DOI
10.1242/dev.120.12.3367
OpenAlex
W2122087650
Cited by
420
References
37
FWCI
5.09
Type
journal article
Language
en
Open access
closed

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