The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Embryonic origin of hemocytes and their relationship to cell death in Drosophila
Abstract
We have studied the embryonic development of Drosophila hemocytes and their conversion into macrophages. Hemocytes derive exclusively from the mesoderm of the head and disperse along several invariant migratory paths throughout the embryo. The origin of hemocytes from the head mesoderm is further supported by the finding that in Bicaudal D, a mutation that lacks all head structures, and in twist snail double mutants, where no mesoderm develops, hemocytes do not form. All embryonic hemocytes behave like a homogenous population with respect to their potential for phagocytosis. Thus, in the wild type, about 80-90% of hemocytes become macrophages during late development. In mutations with an increased amount of cell death (knirps; stardust; fork head), this figure approaches 100%. In contrast, in these mutations, the absolute number of hemocytes does not differ from that in wild type, indicating that cell death does not ‘induce’ the formation of hemocytes. Finally, we show that, in the Drosophila embryo, apoptosis can occur independently of macrophages, since mutations lacking macrophages (Bicaudal D; twist snail double mutants; torso4021) show Abundant cell death.
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Cites
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Cited by
Stuart, L. M., & Ezekowitz, R. A. B. (2005) · Immunity · doi:10.1016/j.immuni.2005.05.002 · Cited by 667
Specification of Drosophila Hematopoietic Lineage by Conserved Transcription Factors
Lebestky, T., Chang, T., Hartenstein, V., & Banerjee, U. (2000) · Science · doi:10.1126/science.288.5463.146 · Cited by 494
Self-citationRequirement for Croquemort in Phagocytosis of Apoptotic Cells in Drosophila
Franc, N. C., Heitzler, P., Alan B., R., Ezekowitz, & White, K. (1999) · Science · doi:10.1126/science.284.5422.1991 · Cited by 373
Söderhäll, I., Bangyeekhun, E., Mayo, S., & Söderhäll, K. (2003) · Developmental & Comparative Immunology · doi:10.1016/s0145-305x(03)00039-9 · Cited by 310
Stramer, B., Wood, W., Galko, M. J., Redd, M. J., Jacinto, A., Parkhurst, S. M., & Martin, P. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200405120 · Cited by 285
Metadata
- Authors
- Tepass, U., Fessler, L. I., Aziz, A., & Hartenstein, V.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1994-07-01
- Volume
- 120
- Issue
- 7
- Pages
- 1829-1837
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2141932361
- Cited by
- 420
- References
- 36
- FWCI
- 3.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- Tepass, U., Fessler, L. I., Aziz, A., & Hartenstein, V. (1994). Embryonic origin of hemocytes and their relationship to cell death in Drosophila. Development. https://doi.org/10.1242/dev.120.7.1829
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
