The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Asymmetric localization of numb autonomously determines sibling neuron identity in the Drosophila CNS
Abstract
The central nervous system (CNS) represents an excellent model system for examining how a multitude of unique cell fates are specified. We find that asymmetric localization of the numb protein autonomously controls a binary cell fate decision in the Drosophila CNS. The simplest lineage in the Drosophila CNS is that of the MP2 precursor: it divides unequally to generate the dMP2 and vMP2 neurons. Both are interneurons but project in different directions: dMP2 projects its axon posteriorly while vMP2 projects anteriorly. During MP2 mitosis, numb is localized into dMP2 and excluded from vMP2. Loss of numb transforms dMP2 into vMP2, whereas ectopic numb produces the opposite transformation of vMP2 into dMP2. Thus, numb is asymmetrically localized in the dividing MP2 and is necessary and sufficient to autonomously specify dMP2 neuronal identity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The embryonic development of Drosophila melanogaster
(1938) · Protoplasma · doi:10.1007/bf01613769 · Cited by 2,142
The Embryonic Development of Drosophila melanogaster
Campos-Ortega, J. A., & Hartenstein, V. (1985) · Springer eBooks · doi:10.1007/978-3-662-02454-6 · Cited by 1,404
Rhyu, M. S., Jan, L. Y., & Jan, Y. N. (1994) · Cell · doi:10.1016/0092-8674(94)90112-0 · Cited by 767
Mechanisms of asymmetric cell division: Two Bs or not two Bs, that is the question
Horvitz, H. R., & Herskowitz, I. (1992) · Cell · doi:10.1016/0092-8674(92)90468-r · Cited by 541
Monoclonal antibodies against the Drosophila nervous system.
Fujita, S. C., Zipursky, S. L., Benzer, S., Ferrús, A., & Shotwell, S. L. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.24.7929 · Cited by 529
Uemura, T., Shepherd, S., Ackerman, L., Jan, L. Y., & Jan, Y. N. (1989) · Cell · doi:10.1016/0092-8674(89)90849-0 · Cited by 505
Characterization and localization of the even-skipped protein of Drosophila.
Frasch, M., Hoey, T., Rushlow, C., Doyle, H., & Levine, M. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb04817.x · Cited by 486
Greenwald, I., & Rubin, G. M. (1992) · Cell · doi:10.1016/0092-8674(92)90470-w · Cited by 441
Doe, C. Q. (1992) · Development · doi:10.1242/dev.116.4.855 · Cited by 416
Self-citationA dual function of the Notch gene in Drosophila sensillum development
Hartenstein, V., & Posakony, J. W. (1990) · Developmental Biology · doi:10.1016/0012-1606(90)90147-b · Cited by 336
(1996) · Trends in Genetics · doi:10.1016/0168-9525(96)81394-1 · Cited by 329
Lin, D. M., Fetter, R. D., Kopczynski, C., Grenningloh, G., & Goodman, C. S. (1994) · Neuron · doi:10.1016/0896-6273(94)90045-0 · Cited by 300
Self-citationCampbell, G., Göring, H., Lin, T., Spana, E., Andersson, S., Doe, C. Q., & Tomlinson, A. (1994) · Development · doi:10.1242/dev.120.10.2957 · Cited by 261
Self-citationTepass, U., & Knust, E. (1993) · Developmental Biology · doi:10.1006/dbio.1993.1243 · Cited by 213
Nung Jan, Y., & Yeh Jan, L. (1995) · Neuron · doi:10.1016/0896-6273(95)90235-x · Cited by 178
Neuroblast Specification and Formation Regulated by wingless in the Drosophila CNS
Chu-LaGraff, Q., & Doe, C. Q. (1993) · Science · doi:10.1126/science.8372355 · Cited by 166
Self-citationNature versus nurture: Asymmetric cell divisions in Drosophila bristle development
Posakony, J. W. (1994) · Cell · doi:10.1016/0092-8674(94)90105-8 · Cited by 151
Udolph, G., Prokop, A., Bossing, T., & Technau, G. M. (1993) · Development · doi:10.1242/dev.118.3.765 · Cited by 134
Delta Function Is Required for Bristle Organ Determination and Morphogenesis in Drosophila
Parks, A. L., & Muskavitch, M. A. T. (1993) · Developmental Biology · doi:10.1006/dbio.1993.1151 · Cited by 108
Huff, R., Furst, A., & Mahowald, A. P. (1989) · Developmental Biology · doi:10.1016/0012-1606(89)90085-7 · Cited by 80
Menne, T. V., & Klämbt, C. (1994) · Development · doi:10.1242/dev.120.1.123 · Cited by 70
Cited by
Regulatory Mechanisms in Stem Cell Biology
Morrison, S. J., Shah, N. M., & Anderson, D. J. (1997) · Cell · doi:10.1016/s0092-8674(00)81867-x · Cited by 1,043
Asymmetric cell division: recent developments and their implications for tumour biology
Knoblich, J. A. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3010 · Cited by 578
Asymmetric Localization of a Mammalian Numb Homolog during Mouse Cortical Neurogenesis
Zhong, W., Feder, J. N., Jiang, M.-M., Jan, L. Y., & Jan, Y. N. (1996) · Neuron · doi:10.1016/s0896-6273(00)80279-2 · Cited by 478
Numb Antagonizes Notch Signaling to Specify Sibling Neuron Cell Fates
Spana, E. P., & Doe, C. Q. (1996) · Neuron · doi:10.1016/s0896-6273(00)80277-9 · Cited by 428
Self-citationSchmid, A., Chiba, A., & Doe, C. Q. (1999) · Development · doi:10.1242/dev.126.21.4653 · Cited by 417
Self-citation
Metadata
- Authors
- Spana, E. P., Kopczynski, C., Goodman, C. S., & Doe, C. Q.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1995-11-01
- Volume
- 121
- Issue
- 11
- Pages
- 3489-3494
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2143970121
- Cited by
- 256
- References
- 21
- FWCI
- 7.11
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
