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Neuroblast Specification and Formation Regulated by wingless in the Drosophila CNS
Abstract
The Drosophila central nervous system (CNS) develops from a heterogeneous population of neural stem cells (neuroblasts), yet the genes regulating neuroblast determination remain unknown. The segmentation gene wingless is regionally expressed in the neuroectoderm from which neuroblasts develop. A conditional wingless mutation is used to inactivate CNS function without affecting segmentation. The stripe of wingless-expressing neuroectoderm generates apparently normal neuroblasts after wingless inactivation; however, adjacent anterior and posterior neuroectoderm requires wingless nonautonomously for subsequent neuroblast determination and formation. Loss of wingless results in the absence or duplication of identified neuroblasts, highlighting its role in generating neuroblast diversity in the CNS.
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Cited by
Peifer, M., Sweeton, D., Casey, M., & Wieschaus, E. (1994) · Development · doi:10.1242/dev.120.2.369 · Cited by 426
Targeted disruption of the Wnt2 gene results in placentation defects
Monkley, S. J., Delaney, S. J., Pennisi, D. J., Christiansen, J. H., & Wainwright, B. J. (1996) · Development · doi:10.1242/dev.122.11.3343 · Cited by 357
Weiss, J. B., Von Ohlen, T., Mellerick, D. M., Dressler, G., Doe, C. Q., & Scott, M. P. (1998) · Genes & Development · doi:10.1101/gad.12.22.3591 · Cited by 236
“The pattern of Eve is a sensitive indicator for normal cell fates within neuroblast cell lineages (Duffy et al. 1991; Chu-LaGraff and Doe 1993; Yang et al. 1993, 1997; Zhang et al. 1994; Chu-LaGraff et al. 1995).”
BackgroundResultInfluentialSelf-citationMa, C., & Moses, K. (1995) · Development · doi:10.1242/dev.121.8.2279 · Cited by 210
McDonald, J. A., Holbrook, S., Isshiki, T., Weiss, J., Doe, C. Q., & Mellerick, D. M. (1998) · Genes & Development · doi:10.1101/gad.12.22.3603 · Cited by 162
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Metadata
- Authors
- Chu-LaGraff, Q., & Doe, C. Q.
- Venue
- Science
- Published
- 1993-09-17
- Volume
- 261
- Issue
- 5128
- Pages
- 1594-1597
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2021210221
- Cited by
- 166
- References
- 0
- FWCI
- 5.37
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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