The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
The homeobox gene repo is required for the differentiation and maintenance of glia function in the embryonic nervous system of Drosophila melanogaster
Abstract
We describe the cloning, expression and phenotypic characterisation of repo, a gene from Drosophila melanogaster that is essential for the differentiation and maintenance of glia function. It is not, however, required for the initial determination of glial cells. In the embryo, the gene, which encodes a homeodomain protein, is expressed exclusively in all developing glia and closely related cells in both the central and peripheral nervous systems. The only observed exceptions in the CNS are the midline glia derived from the mesectoderm and two of three segmental nerve root glial cells. Using a polyclonal antibody we traced the spatial and temporal pattern of the protein expression in detail. Embryos homozygous for null alleles of the protein exhibit late developmental defects in the nervous system, including a reduction in the number of glial cells, disrupted fasciculation of axons, and the inhibition of ventral nerve cord condensation. The expression of an early glial-specific marker is unaffected in such homozygotes. By contrast, the expression of late glial-specific markers is either substantially reduced or absent. The specificity of expression is also observed in the locust Schistocerca gregaria and is thus evolutionarily conserved.
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Citations
Cites
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The Genetics and Biology of Drosophila
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The structure and function of the homeodomain
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Pax-3, a novel murine DNA binding protein expressed during early neurogenesis.
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Cited by
glial cells missing: a genetic switch that controls glial versus neuronal fate
Jones, B. W., Fetter, R. D., Tear, G., & Goodman, C. S. (1995) · Cell · doi:10.1016/0092-8674(95)90280-5 · Cited by 450
The Embryonic Central Nervous System Lineages ofDrosophila melanogaster
Schmidt, H., Rickert, C., Bossing, T., Vef, O., Urban, J., & Technau, G. M. (1997) · Developmental Biology · doi:10.1006/dbio.1997.8660 · Cited by 428
Self-citationPeripheral Glia Direct Axon Guidance across the CNS/PNS Transition Zone
Sepp, K. J., Schulte, J., & Auld, V. J. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0411 · Cited by 290
Genetic control of Drosophila nerve cord development
Skeath, J. B., & Thor, S. (2003) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(03)00007-2 · Cited by 279
Isshiki, T., Takeichi, M., & Nose, A. (1997) · Development · doi:10.1242/dev.124.16.3099 · Cited by 148
Ramirez, M. D., Bui, T. N., & Katz, P. S. (2024) · Journal of Comparative Neurology · doi:10.1002/cne.25628 · Cited by 10
Metadata
- Authors
- Halter, D. A., Urban, J., Rickert, C., Ner, S. S., Ito, K., Travers, A. A., & Technau, G. M.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1995-02-01
- Volume
- 121
- Issue
- 2
- Pages
- 317-332
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2177609029
- Cited by
- 373
- References
- 55
- FWCI
- 6.28
- Type
- journal article
- Language
- en
- Open access
- closed
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