The DOI matches its Crossref record.
Control of neuronal pathway selection by the Drosophila LIM homeodomain gene apterous
Abstract
The Drosophila apterous gene encodes a LIM homeo-domain protein expressed embryonically in a small subset of differentiating neurons. To establish the identity of these neurons and to study the role of apterous in their development, we made apterous promoter fusions to an axon-targeted reporter gene. We found that all apterous-expressing neurons are interneurons that choose a single pathway within the developing central nervous system. In apterous mutants, these neurons choose incorrect pathways and fail to fasciculate with one another. Our results indicate that apterous functions to control neuronal pathway selection and suggest that other vertebrate and invertebrate members of the LIM homeodomain class of proteins may serve similar functions.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells
Ahlgren, U., Pfaff, S. L., Jessell, T. M., Edlund, T., & Edlund, H. (1997) · Nature · doi:10.1038/385257a0 · Cited by 688
LIM domains: multiple roles as adapters and functional modifiers in protein interactions
Dawid, I. B., Breen, J. J., & Toyama, R. (1998) · Trends in Genetics · doi:10.1016/s0168-9525(98)01424-3 · Cited by 600
Riddle, R. D., Ensini, M., Nelson, C., Tsuchida, T., Jessell, T. M., & Tabin, C. (1995) · Cell · doi:10.1016/0092-8674(95)90103-5 · Cited by 478
The last common bilaterian ancestor
Erwin, D. H., & Davidson, E. H. (2002) · Development · doi:10.1242/dev.129.13.3021 · Cited by 320
Altun-Gultekin, Z., Andachi, Y., Tsalik, E. L., Pilgrim, D., Kohara, Y., & Hobert, O. (2001) · Development · doi:10.1242/dev.128.11.1951 · Cited by 286
Hobert, O., Mori, I., Yamashita, Y., Honda, H., Ohshima, Y., Liu, Y., & Ruvkun, G. (1997) · Neuron · doi:10.1016/s0896-6273(00)80944-7 · Cited by 262
Comparison of early nerve cord development in insects and vertebrates
Arendt, D., & Nübler-Jung, K. (1999) · Development · doi:10.1242/dev.126.11.2309 · Cited by 258
Jurata, L. W., Pfaff, S. L., & Gill, G. N. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.6.3152 · Cited by 164
Enriquez, J., Venkatasubramanian, L., Baek, M., Peterson, M., Aghayeva, U., & Mann, R. S. (2015) · Neuron · doi:10.1016/j.neuron.2015.04.011 · Cited by 95
Isl1 is required for multiple aspects of motor neuron development
Liang, X., Song, M.-R., Xu, Z., Lanuza, G. M., Liu, Y., Zhuang, T., Chen, Y., Pfaff, S. L., Evans, S. M., & Sun, Y. (2011) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2011.04.007 · Cited by 100
Homeodomain transcription factors in the development of subsets of hindbrain reticulospinal neurons
Cepeda-Nieto, A. C., Pfaff, S. L., & Varela-Echavarría, A. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.06.016 · Cited by 50
Simmons, D. K., Pang, K., & Martindale, M. Q. (2012) · EvoDevo · doi:10.1186/2041-9139-3-2 · Cited by 38
A branching gene regulatory network dictating different aspects of a neuronal cell identity
Stratmann, J., Ekman, H., & Thor, S. (2019) · Development · doi:10.1242/dev.174300 · Cited by 11
Self-citation
Metadata
- Authors
- Lundgren, S. E., Callahan, C. A., Thor, S., & Thomas, J. B.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1995-06-01
- Volume
- 121
- Issue
- 6
- Pages
- 1769-1773
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2440398508
- Cited by
- 191
- References
- 0
- FWCI
- 4.57
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
