The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
A branching gene regulatory network dictating different aspects of a neuronal cell identity
Abstract
The nervous system displays a daunting cellular diversity. Neuronal subtypes differ from each other in several aspects, including their neurotransmitter expression and axon projection. These aspects can converge, but can also diverge, such that neurons expressing the same neurotransmitter may project axons to different targets. It is not well understood how regulatory programs converge/diverge to associate/dissociate different cell fate features. Studies of the Drosophila Tv1 neurons have identified a regulatory cascade, ladybird early→collier→apterous/eyes absent→dimmed, that specifies Tv1 neurotransmitter expression. Here, we conduct genetic and transcriptome analysis to address how other aspects of Tv1 cell fate are governed. We find that an initiator terminal selector gene triggers a feedforward loop that branches into different subroutines, each of which establishes different features of this one unique neuronal cell fate.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Similarly, in the Drosophila brain, complex regulatory cascades of gene expression establish specific features of Tv1 neurons such as neurite morphology or neurotransmitter identity (55).”
From Behavior-related gene regulatory networks: A new level of organization in the brain (2020) · cites this paper as [55]
Citations
Cites
Near-optimal probabilistic RNA-seq quantification
Bray, N. L., Pimentel, H., Melsted, P., & Pachter, L. (2016) · Nature Biotechnology · doi:10.1038/nbt.3519 · Cited by 9,723
The embryonic development of Drosophila melanogaster
Campos‐Ortega, J. A., & Hartenstein, V. (1938) · PROTOPLASMA · doi:10.1007/bf01613769 · Cited by 2,156
An optimized transgenesis system for Drosophila using germ-line-specific φC31 integrases
Bischof, J., Maeda, R., Hediger, M., Karch, F., & Basler, K. (2007) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0611511104 · Cited by 1,959
Dopamine neuron systems in the brain: An update
Björklund, A., & Dunnett, S. B. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.03.006 · Cited by 1,777
The Embryonic Development of Drosophila melanogaster
Campos‐Ortega, J. A., & Hartenstein, V. (1985) · Springer eBooks · doi:10.1007/978-3-662-02454-6 · Cited by 1,405
Hökfelt, T. G. M., Broberger, C., Xu, Q., Sergeyev, V., Ubink, R., & Diez, M. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(00)00010-1 · Cited by 610
Eukaryotic start and stop translation sites
Cavener, D. R., & Ray, S. C. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.12.3185 · Cited by 584
The Embryonic Central Nervous System Lineages ofDrosophila melanogaster
Bossing, T., Udolph, G., Doe, C. Q., & Technau, G. M. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0240 · Cited by 524
Drosophila Futsch/22C10 Is a MAP1B-like Protein Required for Dendritic and Axonal Development
Hummel, T., Krukkert, K., Roos, J., Davis, G. W., & Klämbt, C. (2000) · Neuron · doi:10.1016/s0896-6273(00)81169-1 · Cited by 464
The Embryonic Central Nervous System Lineages ofDrosophila melanogaster
Schmidt, H., Rickert, C., Bossing, T., Vef, O., Urban, J., & Technau, G. M. (1997) · Developmental Biology · doi:10.1006/dbio.1997.8660 · Cited by 429
Cited by
Behavior-related gene regulatory networks: A new level of organization in the brain
Sinha, S., Jones, B. M., Traniello, I. M., Bukhari, S. A., Halfon, M. S., Hofmann, H. A., Huang, S., Katz, P. S., Keagy, J., Lynch, V. J., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1921625117 · Cited by 85
Metadata
- Authors
- Stratmann, J., Ekman, H., & Thor, S.
- Affiliations
- Linkoping University 1 Department of Clinical and Experimental Medicine , , SE-581 85 Linkoping , Sweden
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2019-03-15
- Volume
- 146
- Issue
- 6
- ISSN
- 1477-9129
- 0950-1991
- Cited by
- 11
- References
- 63
- Language
- en
- Funders
- University of Iowa (2017-0440601)
- Vetenskapsrådet (621-2013-5258, 2017-04061)
- Knut och Alice Wallenbergs Stiftelse (KAW2011.0165, KAW2017.0312, KAW2012.0101)
- Cancerfonden (140780, 150663, CAN2017/257)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: A branching gene regulatory network dictating different aspects of a neuronal cell identity. https://app.cochat.ai/papers/10.1242/dev.174300
- The paper
- Stratmann, J., Ekman, H., & Thor, S. (2019). A branching gene regulatory network dictating different aspects of a neuronal cell identity. Development. https://doi.org/10.1242/dev.174300
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
