The DOI matches its Crossref record.
Localization of oskar RNA regulates oskar translation and requires Oskar protein
Abstract
The site of oskar RNA and protein localization within the oocyte determines where in the embryo primordial germ cells form and where the abdomen develops. Initiation of oskar RNA localization requires the activity of several genes. We show that ovaries mutant for any of these genes lack Oskar protein. Using various transgenic constructs we have determined that sequences required for oskar RNA localization and translational repression map to the oskar 3′UTR, while sequences involved in the correct temporal activation of translation reside outside the oskar 3′UTR. Upon localization of oskar RNA and protein at the posterior pole, Oskar protein is required to maintain local- ization of oskar RNA throughout oogenesis. Stable anchoring of a transgenic reporter RNA at the posterior pole is disrupted by oskar nonsense mutations. We propose that initially localization of oskar RNA permits translation into Oskar protein and that subsequently Oskar protein regulates its own RNA localization through a positive feedback mechanism.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Toyooka, Y., Tsunekawa, N., Takahashi, Y., Matsui, Y., Satoh, M., & Noce, T. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(00)00283-5 · Cited by 548
The power of the 3′ UTR: translational control and development.
Kuersten, S., & Goodwin, E. B. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1125 · Cited by 530
Biogenesis and germline functions of piRNAs
Klattenhoff, C., & Theurkauf, W. (2008) · Development · doi:10.1242/dev.006486 · Cited by 517
CONTROL OF TRANSLATION INITIATION IN ANIMALS
Gray, N. K., & Wickens, M. (1998) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.14.1.399 · Cited by 503
RNA LOCALIZATION IN DEVELOPMENT
Bashirullah, A., Cooperstock, R. L., & Lipshitz, H. D. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.335 · Cited by 339
Nakamura, A., Amikura, R., Hanyu, K., & Kobayashi, S. (2001) · Development · doi:10.1242/dev.128.17.3233 · Cited by 334
Splicing of oskar RNA in the nucleus is coupled to its cytoplasmic localization
Hachet, O., & Ephrussi, A. (2004) · Nature · doi:10.1038/nature02521 · Cited by 332
Axis formation during Drosophila oogenesis
Riechmann, V., & Ephrussi, A. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00207-0 · Cited by 274
Assembly of the Drosophila germ plasm
Mahowald, A. P. (2001) · International Review of Cytology · doi:10.1016/s0074-7696(01)03007-8 · Cited by 258
The neuronal RNA binding protein Nova-1 recognizes specific RNA targets in vitro and in vivo
Buckanovich, R. J., & Darnell, R. B. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.6.3194 · Cited by 217
Kharel, K., Tindell, S. J., Kemph, A., Schmidtke, R., Alexander, E., Lynch, J. A., & Arkov, A. L. (2024) · Development · doi:10.1242/dev.202877 · Cited by 4
Metadata
- Authors
- Rongo, C., Gavis, E. R., & Lehmann, R.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1995-09-01
- Volume
- 121
- Issue
- 9
- Pages
- 2737-2746
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2181461782
- Cited by
- 212
- References
- 0
- FWCI
- 3.79
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
