The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Inhibition of testicular germ cell apoptosis and differentiation in mice misexpressing Bcl-2 in spermatogonia
Abstract
During normal spermatogenesis, more than half of the germ cells undergo apoptosis, but the physiological significance and molecular mechanisms of this programmed cell death are largely unknown. Because Bcl-2 functions as a death repressor, we have investigated the effect of misexpressing Bcl-2 in spermatogonia in transgenic mice using the human bcl-2 cDNA under the control of the human polypeptide chain elongation factor 1α (EF-1α) promoter. In the 2-week-old transgenic testes, exogenous Bcl-2 was expressed in spermatogonia and massive accumulation of spermatogonia was observed in seminiferous tubules by 4 weeks. At this time, only a few spermatocytes were apparent, and the accumulated cells degenerated, leading to vacuolization in some seminiferous tubules by 7 weeks. In older transgenic mice, abnormal accumulation of spermatogonia and degeneration of these germ cells was still observed, but some seminiferous tubules in which the level of Bcl-2 expression was reduced recovered normal spermatogenesis. These observations indicate that spermatogonial apoptosis is part of the normal program of mammalian spermatogenesis and is regulated by a pathway affected by Bcl-2.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death
Oltval, Z. N., Milliman, C. L., & Korsmeyer, S. J. (1993) · Cell · doi:10.1016/0092-8674(93)90509-o · Cited by 6,003
McDonnell, T. J., Deane, N., Platt, F. M., Nunez, G., Jaeger, U., McKearn, J. P., & Korsmeyer, S. J. (1989) · Cell · doi:10.1016/0092-8674(89)90174-8 · Cited by 1,213
Cited by
Strasser, A., O'Connor, L., & Dixit, V. M. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.217 · Cited by 1,351
Imai, H., & Nakagawa, Y. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01197-8 · Cited by 767
Disruption of histone methylation in developing sperm impairs offspring health transgenerationally
Siklenka, K., Erkek, S., Godmann, M., Lambrot, R., McGraw, S., Lafleur, C., Cohen, T., Xia, J., Suderman, M., Hallett, M., et al. (2015) · Science · doi:10.1126/science.aab2006 · Cited by 521
de Rooij, D. G., & Grootegoed, J. A. (1998) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(98)80109-9 · Cited by 537
Acute Testicular Ischemia Results in Germ Cell-Specific Apoptosis in the Rat1
Turner, T. T., Tung, K. S. K., Tomomasa, H., & Wilson, L. W. (1997) · Biology of Reproduction · doi:10.1095/biolreprod57.6.1267 · Cited by 364
Lue, Y.-H., Sinha Hikim, A. P., Swerdloff, R. S., Im, P., Taing, K. S., Bui, T., Leung, A., & Wang, C. (1999) · Endocrinology · doi:10.1210/endo.140.4.6629 · Cited by 313
Lee, J., Richburg, J. H., Shipp, E. B., Meistrich, M. L., & Boekelheide, K. (1999) · Endocrinology · doi:10.1210/en.140.2.852 · Cited by 297
Role of caspases in male infertility
Said, T. M. (2004) · Human Reproduction Update · doi:10.1093/humupd/dmh003 · Cited by 276
Sakkas, D., Seli, E., Bizzaro, D., Tarozzi, N., & Manicardi, G. C. (2003) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)61886-x · Cited by 275
Testicular degeneration in Bclw-deficient mice
Ross, A. J., Waymire, K. G., Moss, J. E., Parlow, A. F., Skinner, M. K., Russell, L. D., & MacGregor, G. R. (1998) · Nature Genetics · doi:10.1038/ng0398-251 · Cited by 269
Metadata
- Authors
- Furuchi, T., Masuko, K., Nishimune, Y., Obinata, M., & Matsui, Y.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1996-06-01
- Volume
- 122
- Issue
- 6
- Pages
- 1703-1709
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2188000876
- Cited by
- 248
- References
- 2
- FWCI
- 13.02
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
