The DOI matches its Crossref record; 100 of the 100 references it cites were found in a registry or an index.
Role of caspases in male infertility
Abstract
Apoptosis is characterized by a variety of changes resulting in the recognition and phagocytosis of apoptotic cells. Caspases (cysteinyl aspartate-specific proteinases) play a central role in the regulation of apoptosis in the human seminiferous epithelium. They are expressed as inactive proenzymes and participate in a cascade triggered in response to pro-apoptotic signals. To date, 14 caspases have been implicated in the human apoptotic pathway cascade. Among these, caspase-3 is considered to be a major executioner protease. Since apoptosis is a universal suicide system in almost all cells, a close control via molecular, endocrine and physical factors establishes homeostasis of cell growth and death. The proper regulation of the caspase cascade plays an important role in sperm differentiation and testicular maturity. However, caspases have been implicated in the pathogenesis of multiple andrological pathologies such as impaired spermatogenesis, decreased sperm motility and increased levels of sperm DNA fragmentation, testicular torsion, varicocele and immunological infertility. Future research may provide a better understanding of the regulation of caspases, which may help us to manipulate the apoptotic machinery for therapeutic benefits. In this review, we summarize the consequences of caspase activation, aiming to clarify their role in the pathogenesis of male infertility.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Green, D. R., & Reed, J. C. (1998) · Science · doi:10.1126/science.281.5381.1309 · Cited by 8,965
Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S., & Wang, X. (1997) · Cell · doi:10.1016/s0092-8674(00)80434-1 · Cited by 7,289
Thornberry, N. A., & Lazebnik, Y. (1998) · Science · doi:10.1126/science.281.5381.1312 · Cited by 6,887
Hengartner, M. O. (2000) · Nature · doi:10.1038/35037710 · Cited by 5,779
Vermes, I., Haanen, C., Steffens-Nakken, H., & Reutellingsperger, C. (1995) · Journal of Immunological Methods · doi:10.1016/0022-1759(95)00072-i · Cited by 5,410
The Bcl-2 Protein Family: Arbiters of Cell Survival
Adams, J. M., & Cory, S. (1998) · Science · doi:10.1126/science.281.5381.1322 · Cited by 5,332
NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses
Ghosh, S., May, M. J., & Kopp, E. B. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.225 · Cited by 5,182
Caspases: the executioners of apoptosis
COHEN, G. M. (1997) · Biochemical Journal · doi:10.1042/bj3260001 · Cited by 4,719
Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis
Li, H., Zhu, H., Xu, C.-J., & Yuan, J. (1998) · Cell · doi:10.1016/s0092-8674(00)81590-1 · Cited by 4,445
Emerging roles of caspase-3 in apoptosis
Porter, A. G., & Jänicke, R. U. (1999) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4400476 · Cited by 3,855
Cited by
Oxidative stress, DNA damage and apoptosis in male infertility: A clinical approach
Agarwal, A., & Said, T. M. (2005) · BJU International · doi:10.1111/j.1464-410x.2005.05328.x · Cited by 472
Self-citationSperm chromatin structure and male fertility: biological and clinical aspects
Erenpreiss, J., Spano, M., Erenpreisa, J., Bungum, M., & Giwercman, A. (2006) · Asian Journal of Andrology · doi:10.1111/j.1745-7262.2006.00112.x · Cited by 304
Impact of folate and homocysteine metabolism on human reproductive health
Forges, T., Monnier-Barbarino, P., Alberto, J. M., Guéant-Rodriguez, R. M., Daval, J. L., & Guéant, J. L. (2007) · Human Reproduction Update · doi:10.1093/humupd/dml063 · Cited by 300
Implication of apoptosis in sperm cryoinjury
Said, T. M., Gaglani, A., & Agarwal, A. (2010) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2010.05.011 · Cited by 278
Self-citationThe targeting and functions of miRNA-383 are mediated by FMRP during spermatogenesis
Tian, H., Cao, Y.-X., Zhang, X.-S., Liao, W.-P., Yi, Y.-H., Lian, J., Liu, L., Huang, H.-L., Liu, W.-J., Yin, M.-M., et al. (2013) · Cell Death & Disease · doi:10.1038/cddis.2013.138 · Cited by 61
Metadata
- Authors
- Said, T. M.
- Venue
- Human Reproduction Update
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-01-01
- Volume
- 10
- Issue
- 1
- Pages
- 39-51
- ISSN
- 1355-4786 (ISSN-L)
- 1460-2369
- OpenAlex
- W2061050258
- Cited by
- 276
- References
- 100
- FWCI
- 10.99
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Role of caspases in male infertility. https://app.cochat.ai/papers/10.1093/humupd/dmh003
- The paper
- Said, T. M. (2004). Role of caspases in male infertility. Human Reproduction Update. https://doi.org/10.1093/humupd/dmh003
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
