The DOI matches its Crossref record.
Serrate-mediated activation of Notch is specifically blocked by the product of the gene fringe in the dorsal compartment of the Drosophila wing imaginal disc
Abstract
In the developing imaginal wing disc of Drosophila, cells at the dorsoventral boundary require localized Notch activity for specification of the wing margin. The Notch ligands Serrate and Delta are required on opposite sides of the presumptive wing margin and, even though activated forms of Notch generate responses on both sides of the dorsoventral boundary, each ligand generates a compartment-specific response. In this report we demonstrate that Serrate, which is expressed in the dorsal compartment, does not signal in the dorsal regions due to the action of the fringe gene product. Using ectopic expression, we show that regulation of Serrate by fringe occurs at the level of protein and not Serrate transcription. Furthermore, replacement of the N-terminal region of Serrate with the corresponding region of Delta abolishes the ability of fringe to regulate Serrate without altering Serrate-specific signaling.
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Citations
Cited by
Notch Signaling: Cell Fate Control and Signal Integration in Development
Artavanis-Tsakonas, S., Rand, M. D., & Lake, R. J. (1999) · Science · doi:10.1126/science.284.5415.770 · Cited by 5,909
Fringe is a glycosyltransferase that modifies Notch
Moloney, D. J., Panin, V. M., Johnston, S. H., Chen, J., Shao, L., Wilson, R., Wang, Y., Stanley, P., Irvine, K. D., Haltiwanger, R. S., et al. (2000) · Nature · doi:10.1038/35019000 · Cited by 852
Role of Glycosylation in Development
Haltiwanger, R. S., & Lowe, J. B. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.074043 · Cited by 757
Glycosyltransferase activity of Fringe modulates Notch–Delta interactions
Brückner, K., Perez, L., Clausen, H., & Cohen, S. (2000) · Nature · doi:10.1038/35019075 · Cited by 694
Fringe modulates Notch–ligand interactions
Panin, V. M., Papayannopoulos, V., Wilson, R., & Irvine, K. D. (1997) · Nature · doi:10.1038/43191 · Cited by 586
Harada, H., Kettunen, P., Jung, H.-S., Mustonen, T., Wang, Y. A., & Thesleff, I. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.1.105 · Cited by 517
Ligand endocytosis drives receptor dissociation and activation in the Notch pathway
Parks, A. L., Klueg, K. M., Stout, J. R., & Muskavitch, M. A. T. (2000) · Development · doi:10.1242/dev.127.7.1373 · Cited by 494
Defects in somite formation in lunatic fringe-deficient mice
Zhang, N., & Gridley, T. (1998) · Nature · doi:10.1038/28625 · Cited by 400
Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2
Hicks, C., Johnston, S. H., diSibio, G., Collazo, A., Vogt, T. F., & Weinmaster, G. (2000) · Nature Cell Biology · doi:10.1038/35019553 · Cited by 373
The Notch Ligand, Jagged-1, Influences the Development of Primitive Hematopoietic Precursor Cells
Varnum-Finney, B., Purton, L. E., Yu, M., Brashem-Stein, C., Flowers, D., Staats, S., Moore, K. A., Le Roux, I., Mann, R., Gray, G., et al. (1998) · Blood · doi:10.1182/blood.v91.11.4084 · Cited by 324
Notch as a Mediator of Cell Fate Determination in Hematopoiesis: Evidence and Speculation
Milner, L. A., & Bigas, A. (1999) · Blood · doi:10.1182/blood.v93.8.2431 · Cited by 293
Baladrón, V., Ruiz-Hidalgo, M. J., Nueda, M. L., Díaz-Guerra, M. J. M., García-Ramírez, J. J., Bonvini, E., Gubina, E., & Laborda, J. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.10.001 · Cited by 226
Roles of Glycosylation in Notch Signaling
(2010) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(10)92004-8 · Cited by 136
Metadata
- Authors
- Fleming, R. J., Gu, Y., & Hukriede, N. A.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1997-08-01
- Volume
- 124
- Issue
- 15
- Pages
- 2973-2981
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2143760153
- Cited by
- 255
- References
- 0
- FWCI
- 8.10
- Type
- journal article
- Language
- en
- Open access
- closed
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