The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish
Abstract
The first evident break in left-right symmetry of the primitive zebrafish heart tube is the shift in pattern of BMP4 expression from radially symmetric to left-predominant. The midline heart tube then ‘jogs’ to the left and subsequently loops to the right. We examined 279 mutations, affecting more than 200 genes, and found 21 mutations that perturb this process. Some cause BMP4 to remain radially symmetric. Others randomize the asymmetric BMP4 pattern. Retention of BMP4 symmetry is associated with failure to jog: right-predominance of the BMP4 pattern is associated with reversal of the direction of jogging and looping. Raising BMP4 diffusely throughout the heart, via sonic hedgehog injection, or the blocking of its action by injection of a dominant negative BMP4 receptor, prevent directional jogging or looping. The genes crucial to directing cardiac asymmetry include a subset of those needed for patterning the dorsoventral axis and for notochord and ventral spinal cord development. Thus, the pattern of cardiac BMP4 appears to be in the pathway by which the heart interprets lateralizing signals from the midline.
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Citations
Cites
A homeobox gene essential for zebrafish notochord development
Talbot, W. S., Trevarrow, B., Halpern, M. E., Melby, A. E., Farr, G., Postlethwait, J. H., Jowett, T., Kimmel, C. B., & Kimelman, D. (1995) · Nature · doi:10.1038/378150a0 · Cited by 465
Zebrafish pigmentation mutations and the processes of neural crest development
Kelsh, R. N., Brand, M., Jiang, Y.-J., Heisenberg, C.-P., Lin, S., Haffter, P., Odenthal, J., Mullins, M. C., Eeden, F. J. M. V., Furutani-Seiki, M., et al. (1996) · Development · doi:10.1242/dev.123.1.369 · Cited by 455
Self-citationHalpern, M. E., Thisse, C., Ho, R. K., Thisse, B., Riggleman, B., Trevarrow, B., Weinberg, E. S., Postlethwait, J. H., & Kimmel, C. B. (1995) · Development · doi:10.1242/dev.121.12.4257 · Cited by 178
Cited by
1 Developmental roles and clinical significance of Hedgehog signaling
McMahon, A. P., Ingham, P. W., & Tabin, C. J. (2003) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(03)53002-2 · Cited by 772
Reifers, F., Böhli, H., Walsh, E. C., Crossley, P. H., Stainier, D. Y. R., & Brand, M. (1998) · Development · doi:10.1242/dev.125.13.2381 · Cited by 686
lefty-1 Is Required for Left-Right Determination as a Regulator of lefty-2 and nodal
Meno, C., Shimono, A., Saijoh, Y., Yashiro, K., Mochida, K., Ohishi, S., Noji, S., Kondoh, H., & Hamada, H. (1998) · Cell · doi:10.1016/s0092-8674(00)81472-5 · Cited by 537
Long, S., Ahmad, N., & Rebagliati, M. (2003) · Development · doi:10.1242/dev.00436 · Cited by 366
Sonic hedgehog is not required for the induction of medial floor plate cells in the zebrafish
Schauerte, H. E., Eeden, F. J. M. V., Fricke, C., Odenthal, J., Strähle, U., & Haffter, P. (1998) · Development · doi:10.1242/dev.125.15.2983 · Cited by 349
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Metadata
- Authors
- Chen, J.-N., Eeden, F. J. M. V., Warren, K. S., Chin, A., Nüsslein-Volhard, C., Haffter, P., & Fishman, M. C.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1997-11-01
- Volume
- 124
- Issue
- 21
- Pages
- 4373-4382
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2107071468
- Cited by
- 325
- References
- 3
- FWCI
- 6.30
- Type
- journal article
- Language
- en
- Open access
- closed
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