The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing
Abstract
The secreted protein Hedgehog (Hh) transmits a signal from posterior to anterior cells that is essential for limb development in insects and vertebrates. In Drosophila, Hh has been thought to act primarily to induce localized expression of Decapentaplegic and Wingless which in turn relay patterning cues at long range. We report here that Hh plays an additional role in patterning the wing. By replacing endogenous Hh activity with that of a membranetethered form of Hh, we show that Hh acts directly to pattern the central region of the wing, in addition to its role as an inducer of Dpp. Comparing the biological activities of secreted and membrane-tethered Hh provides evidence that Hh forms a local concentration gradient and functions as a concentration-dependent morphogen in the fly wing.
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Lee, J. J., von Kessler, D. P., Parks, S., & Beachy, P. A. (1992) · Cell · doi:10.1016/0092-8674(92)90264-d · Cited by 581
Cited by
1 Developmental roles and clinical significance of Hedgehog signaling
McMahon, A. P., Ingham, P. W., & Tabin, C. J. (2003) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(03)53002-2 · Cited by 772
Do Morphogen Gradients Arise by Diffusion?
Lander, A. D., Nie, Q., & Wan, F. Y. M. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00179-x · Cited by 406
Hedgehog–GLI signaling and the growth of the brain
Ruiz i Altaba, A., Palma, V., & Dahmane, N. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn704 · Cited by 376
Baeg, G.-H., Lin, X., Khare, N., Baumgartner, S., & Perrimon, N. (2001) · Development · doi:10.1242/dev.128.1.87 · Cited by 371
Self-Enhanced Ligand Degradation Underlies Robustness of Morphogen Gradients
Eldar, A., Rosin, D., Shilo, B.-Z., & Barkai, N. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00292-2 · Cited by 289
Hedgehog regulates smoothened activity by inducing a conformational switch
Zhao, Y., Tong, C., & Jiang, J. (2007) · Nature · doi:10.1038/nature06225 · Cited by 274
Dessaud, E., Ribes, V., Balaskas, N., Yang, L. L., Pierani, A., Kicheva, A., Novitch, B. G., Briscoe, J., & Sasai, N. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000382 · Cited by 203
Metadata
- Authors
- Strigini, M., & Cohen, S. M.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1997-11-15
- Volume
- 124
- Issue
- 22
- Pages
- 4697-4705
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2166841567
- Cited by
- 297
- References
- 1
- FWCI
- 6.64
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
