The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A single morphogenetic field gives rise to two retina primordia under the influence of the prechordal plate
Open accessAbstract
Two bilaterally symmetric eyes arise from the anterior neural plate in vertebrate embryos. An interesting question is whether both eyes share a common developmental origin or they originate separately. We report here that the expression pattern of a new gene ET reveals that there is a single retina field which resolves into two separate primordia, a suggestion supported by the expression pattern of the Xenopus Pax-6 gene. Lineage tracing experiments demonstrate that retina field resolution is not due to migration of cells in the median region to the lateral parts of the field. Removal of the prechordal mesoderm led to formation of a single retina both in chick embryos and in Xenopus explants. Transplantation experiments in chick embryos indicate that the prechordal plate is able to suppress Pax-6 expression. Our results provide direct evidence for the existence of a single retina field, indicate that the retina field is resolved by suppression of retina formation in the median region of the field, and demonstrate that the prechordal plate plays a primary signaling role in retina field resolution.
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Cites
Homology of the eyeless Gene of Drosophila to the Small eye Gene in Mice and Aniridia in Humans
Quiring, R., Walldorf, U., Kloter, U., & Gehring, W. J. (1994) · Science · doi:10.1126/science.7914031 · Cited by 1,100
Cited by
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Semënov, M. V., Tamai, K., Brott, B. K., Kühl, M., Sokol, S., & He, X. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00290-1 · Cited by 616
Modeling early retinal development with human embryonic and induced pluripotent stem cells
Meyer, J. S., Shearer, R. L., Capowski, E. E., Wright, L. S., Wallace, K. A., McMillan, E. L., Zhang, S.-C., & Gamm, D. M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905245106 · Cited by 601
Li, H.-S., Chen, J.-H., Wu, W., Fagaly, T., Zhou, L., Yuan, W., Dupuis, S., Jiang, Z.-H., Nash, W., Gick, C., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80591-7 · Cited by 462
Self-citationPax6 induces ectopic eyes in a vertebrate
Chow, R. L., Altmann, C. R., Lang, R. A., & Hemmati-Brivanlou, A. (1999) · Development · doi:10.1242/dev.126.19.4213 · Cited by 451
Paganelli, A., Gnazzo, V., Acosta, H., López, S. L., & Carrasco, A. E. (2010) · Chemical Research in Toxicology · doi:10.1021/tx1001749 · Cited by 444
Szeto, D. P., Rodriguez-Esteban, C., Ryan, A. K., O'Connell, S. M., Liu, F., Kioussi, C., Gleiberman, A. S., Izpisua-Belmonte, J. C., & Rosenfeld, M. G. (1999) · Genes & Development · doi:10.1101/gad.13.4.484 · Cited by 426
Hedgehog signalling controls eye degeneration in blind cavefish
Yamamoto, Y., Stock, D. W., & Jeffery, W. R. (2004) · Nature · doi:10.1038/nature02864 · Cited by 274
He, M.-L., Wen, L., Campbell, C. E., Wu, J. Y., & Rao, Y. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.18.10212 · Cited by 120
Self-citationAchberger, K., Haderspeck, J. C., Kleger, A., & Liebau, S. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.05.005 · Cited by 75
Metadata
- Authors
- Li, H.-S., Tierney, C., Wen, L., Wu, J. Y., & Rao, Y.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1997-02-01
- Volume
- 124
- Issue
- 3
- Pages
- 603-615
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2126245868
- Cited by
- 275
- References
- 1
- FWCI
- 6.64
- Type
- journal article
- Language
- en
- Open access
- green
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