The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Eyeless initiates the expression of both sine oculis and eyes absent during Drosophila compound eye development
Abstract
The Drosophila Pax-6 gene eyeless acts high up in the genetic hierarchy involved in compound eye development and can direct the formation of extra eyes in ectopic locations. Here we identify sine oculis and eyes absent as two mediators of the eye-inducing activity of eyeless. We show that eyeless induces and requires the expression of both genes independently during extra eye development. During normal eye development, eyeless is expressed earlier than and is required for the expression of sine oculis and eyes absent, but not vice versa. Based on the results presented here and those of others, we propose a model in which eyeless induces the initial expression of both sine oculis and eyes absent in the eye disc. sine oculis and eyes absent then appear to participate in a positive feedback loop that regulates the expression of all three genes. In contrast to the regulatory interactions that occur in the developing eye disc, we also show that in the embryonic head, sine oculis acts in parallel to eyeless and twin of eyeless, a second Pax-6 gene from Drosophila. Recent studies in vertebrate systems indicate that the epistatic relationships among the corresponding vertebrate homologs are very similar to those observed in Drosophila.
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Citations
Cites
Homology of the eyeless Gene of Drosophila to the Small eye Gene in Mice and Aniridia in Humans
Quiring, R., Walldorf, U., Kloter, U., & Gehring, W. J. (1994) · Science · doi:10.1126/science.7914031 · Cited by 1,100
Self-citationLee, J. J., von Kessler, D. P., Parks, S., & Beachy, P. A. (1992) · Cell · doi:10.1016/0092-8674(92)90264-d · Cited by 581
Cited by
Brogiolo, W., Stocker, H., Ikeya, T., Rintelen, F., Fernandez, R., & Hafen, E. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00068-9 · Cited by 1,255
Akt regulates growth by directly phosphorylating Tsc2
Potter, C. J., Pedraza, L. G., & Xu, T. (2002) · Nature Cell Biology · doi:10.1038/ncb840 · Cited by 959
Pax 6: mastering eye morphogenesis and eye evolution
Gehring, W. J., & Ikeo, K. (1999) · Trends in Genetics · doi:10.1016/s0168-9525(99)01776-x · Cited by 758
Self-citationSix1 is required for the early organogenesis of mammalian kidney
Xu, P.-X., Zheng, W., Huang, L., Maire, P., Laclef, C., & Silvius, D. (2003) · Development · doi:10.1242/dev.00536 · Cited by 361
Six3 overexpression initiates the formation of ectopic retina
Loosli, F., Winkler, S., & Wittbrodt, J. (1999) · Genes & Development · doi:10.1101/gad.13.6.649 · Cited by 257
Metadata
- Authors
- Halder, G., Callaerts, P., Flister, S., Walldorf, U., Kloter, U., & Gehring, W. J.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1998-06-15
- Volume
- 125
- Issue
- 12
- Pages
- 2181-2191
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2172162107
- Cited by
- 391
- References
- 2
- FWCI
- 8.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- Halder, G., Callaerts, P., Flister, S., Walldorf, U., Kloter, U., & Gehring, W. J. (1998). Eyeless initiates the expression of both sine oculis and eyes absent during Drosophila compound eye development. Development. https://doi.org/10.1242/dev.125.12.2181
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