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Female mouse germ cells form synchronously dividing cysts
Abstract
Oocytes from many invertebrates initiate development within distinctive cysts of interconnected cells, which are formed through synchronous divisions of a progenitor cell. Recently, processes underlying cyst formation have been extensively characterized at the molecular level in Drosophila. Defects in this process cause sterility in female flies. Early female mouse germ cells are organized as cell clusters as well, but it is uncertain whether these groups are similar to the cysts of invertebrates. We find that mouse germ cells are connected by intercellular bridges in the ovaries of 11.5 to 17.5 days postcoitum embryos; microtubules and organelles have been observed within these bridges. Confocal microscopy shows that cells within mouse clusters divide synchronously and frequently correspond in number to powers of two. Thus, female mouse germ cell clusters exhibit key characteristics of invertebrate germline cysts indicating that the process of germline cyst formation is conserved in the mouse.
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Cited by
Transgenerational Epigenetic Effects
Youngson, N. A., & Whitelaw, E. (2008) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.9.081307.164445 · Cited by 580
Sex determination, gonadal sex differentiation, and plasticity in vertebrate species
Nagahama, Y., Chakraborty, T., Paul-Prasanth, B., Ohta, K., & Nakamura, M. (2021) · Physiological Reviews · doi:10.1152/physrev.00044.2019 · Cited by 346
Mouse cloning with nucleus donor cells of different age and type
Wakayama, T., & Yanagimachi, R. (2001) · Molecular Reproduction and Development · doi:10.1002/1098-2795(20010401)58:4<376::aid-mrd4>3.0.co;2-l · Cited by 326
Chen, Y., Jefferson, W. N., Newbold, R. R., Padilla-Banks, E., & Pepling, M. E. (2007) · Endocrinology · doi:10.1210/en.2007-0088 · Cited by 268
Self-citationNiu, W., & Spradling, A. C. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2005570117 · Cited by 267
Metadata
- Authors
- Pepling, M. E., & C. Spradling, A.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1998-09-01
- Volume
- 125
- Issue
- 17
- Pages
- 3323-3328
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2144089726
- Cited by
- 439
- References
- 0
- FWCI
- 5.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- Pepling, M. E., & C. Spradling, A. (1998). Female mouse germ cells form synchronously dividing cysts. Development. https://doi.org/10.1242/dev.125.17.3323
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