The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Delta-Notch signalling and the patterning of sensory cell differentiation in the zebrafish ear: evidence from the mind bomb mutant
Abstract
Mechanosensory hair cells in the sensory patches of the vertebrate ear are interspersed among supporting cells, forming a fine-grained pattern of alternating cell types. Analogies with Drosophila mechanosensory bristle development suggest that this pattern could be generated through lateral inhibition mediated by Notch signalling. In the zebrafish ear rudiment, homologues of Notch are widely expressed, while the Delta homologues deltaA, deltaB and deltaD, coding for Notch ligands, are expressed in small numbers of cells in regions where hair cells are soon to differentiate. This suggests that the delta-expressing cells are nascent hair cells, in agreement with findings for Delta1 in the chick. According to the lateral inhibition hypothesis, the nascent hair cells, by expressing Delta protein, would inhibit their neighbours from becoming hair cells, forcing them to be supporting cells instead. The zebrafish mind bomb mutant has abnormalities in the central nervous system, somites, and elsewhere, diagnostic of a failure of Delta-Notch signalling: in the CNS, it shows a neurogenic phenotype accompanied by misregulated delta gene expression. Similar misregulation of delta genes is seen in the ear, along with misregulation of a Serrate homologue, serrateB, coding for an alternative Notch ligand. Most dramatically, the sensory patches in the mind bomb ear consist solely of hair cells, which are produced in great excess and prematurely; at 36 hours post fertilization, there are more than ten times as many as normal, while supporting cells are absent. A twofold increase is seen in the number of otic neurons also. The findings are strong evidence that lateral inhibition mediated by Delta-Notch signalling controls the pattern of sensory cell differentiation in the ear.
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Citations
Cites
Stages of embryonic development of the zebrafish
Kimmel, C. B., Ballard, W. W., Kimmel, S. R., Ullmann, B., & Schilling, T. F. (1995) · Developmental Dynamics · doi:10.1002/aja.1002030302 · Cited by 12,037
The development of Drosophila melanogaster
Ingham, P. (1994) · Trends in Genetics · doi:10.1016/0168-9525(90)90017-z · Cited by 3,149
Artavanis-Tsakonas, S., Matsuno, K., & Fortini, M. E. (1995) · Science · doi:10.1126/science.7716513 · Cited by 1,303
Expression of a Delta homologue in prospective neurons in the chick
Henrique, D., Adam, J., Myat, A., Chitnis, A., Lewis, J., & Ish-Horowicz, D. (1995) · Nature · doi:10.1038/375787a0 · Cited by 992
Self-citationNotch1 is required for the coordinate segmentation of somites
Conlon, R. A., Reaume, A. G., & Rossant, J. (1995) · Development · doi:10.1242/dev.121.5.1533 · Cited by 852
The choice of cell fate in the epidermis of Drosophila
Heitzler, P., & Simpson, P. (1991) · Cell · doi:10.1016/0092-8674(91)90263-x · Cited by 743
Cloning of the zebrafish krox-20 gene (krx-20) and its expression during hindbrain development
Oxtoby, E., & Jowett, T. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.5.1087 · Cited by 697
Chitnis, A., Henrique, D., Lewis, J., Ish-Horowicz, D., & Kintner, C. (1995) · Nature · doi:10.1038/375761a0 · Cited by 675
Self-citationControl of Daughter Cell Fates during Asymmetric Division: Interaction of Numb and Notch
Guo, M., Jan, L. Y., & Jan, Y. N. (1996) · Neuron · doi:10.1016/s0896-6273(00)80278-0 · Cited by 670
Maintenance of somite borders in mice requires the Delta homologue Dll1
de Angelis, M. H., Mclntyre, J., & Gossler, A. (1997) · Nature · doi:10.1038/386717a0 · Cited by 620
Cited by
Bray, S. J. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.94 · Cited by 1,012
Notch signalling pathway mediates hair cell development in mammalian cochlea
Lanford, P. J., Lan, Y., Jiang, R., Lindsell, C., Weinmaster, G., Gridley, T., & Kelley, M. W. (1999) · Nature Genetics · doi:10.1038/6804 · Cited by 485
Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear
Brooker, R., Hozumi, K., & Lewis, J. (2006) · Development · doi:10.1242/dev.02284 · Cited by 330
Self-citationMa, Q., Anderson, D. J., & Fritzsch, B. (2000) · Journal of the Association for Research in Otolaryngology · doi:10.1007/s101620010017 · Cited by 301
Zine, A., Aubert, A., Qiu, J., Therianos, S., Guillemot, F., Kageyama, R., & de Ribaupierre, F. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-13-04712.2001 · Cited by 294
The Notch Ligand JAG1 Is Required for Sensory Progenitor Development in the Mammalian Inner Ear
Kiernan, A. E., Xu, J., & Gridley, T. (2006) · PLoS Genetics · doi:10.1371/journal.pgen.0020004 · Cited by 290
Kiernan, A. E., Cordes, R., Kopan, R., Gossler, A., & Gridley, T. (2005) · Development · doi:10.1242/dev.02002 · Cited by 281
Revisiting cell fate specification in the inner ear
Fekete, D. M., & Wu, D. K. (2002) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(02)00287-8 · Cited by 276
Hes1 is a negative regulator of inner ear hair cell differentiation
Zheng, J. L., Shou, J., Guillemot, F., Kageyama, R., & Gao, W.-Q. (2000) · Development · doi:10.1242/dev.127.21.4551 · Cited by 264
Delta-Notch signalling controls commitment to a secretory fate in the zebrafish intestine
Crosnier, C., Vargesson, N., Gschmeissner, S., Ariza-McNaughton, L., Morrison, A., & Lewis, J. (2005) · Development · doi:10.1242/dev.01644 · Cited by 262
Self-citationDoetzlhofer, A., Basch, M. L., Ohyama, T., Gessler, M., Groves, A. K., & Segil, N. (2009) · Developmental Cell · doi:10.1016/j.devcel.2008.11.008 · Cited by 254
MicroRNA-183 family members regulate sensorineural fates in the inner ear
Li, H., Kloosterman, W., & Fekete, D. M. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4948-09.2010 · Cited by 140
Conservation of neurogenic genes and mechanisms
Chan, Y.-M., & Jan, Y. N. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)00017-3 · Cited by 58
Structural requirements for activity of Mind bomb1 in Notch signaling
Cao, R., Gozlan, O., Airich, A., Tveriakhina, L., Zhou, H., Jiang, H., Cole, P. A., Aster, J. C., Klein, T., Sprinzak, D., et al. (2024) · Structure · doi:10.1016/j.str.2024.07.011 · Cited by 7
Metadata
- Authors
- Haddon, C., Jiang, Y.-J., Smithers, L., & Lewis, J.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1998-12-01
- Volume
- 125
- Issue
- 23
- Pages
- 4637-4644
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2156615417
- Cited by
- 288
- References
- 40
- FWCI
- 5.06
- Type
- journal article
- Language
- en
- Open access
- closed
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