The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Semaphorins act as attractive and repulsive guidance signals during the development of cortical projections
Abstract
Members of the semaphorin family have been implicated in mediating axonal guidance in the nervous system by their ability to collapse growth cones and to function as chemorepellents. The present findings show that recombinant Semaphorin D has similar effects on cortical axons and, in addition, inhibits axonal branching. In contrast, semaphorin E acts as an attractive guidance signal for cortical axons. Attractive effects were only observed when growth cones encountered increasing concentrations or a patterned distribution of Semaphorin E, but not when they are exposed to uniform concentrations of this molecule. Specific binding sites for Semaphorin D and Semaphorin E were present on cortical fibers both in vitro and in vivo at the time when corticofugal projections are established. In situ hybridization analysis revealed that the population of cortical neurons used in our experiments express neuropilin-1 and neuropilin-2, which are essential components of receptors for the class III semaphorins. Moreover, semD mRNA was detected in the ventricular zone of the neocortex whereas semE mRNA was restricted to the subventricular zone. Taken together, these results indicate that semaphorins are bifunctional molecules whose effects depend on their spatial distribution. The coordinated expression of different semaphorins, together with their specific activities on cortical axons, suggests that multiple guidance signals contribute to the formation of precise corticofugal pathways.
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Cites
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Neuropilin Is a Semaphorin III Receptor
Kolodkin, A. L., Levengood, D. V., Rowe, E. G., Tai, Y.-T., Giger, R. J., & Ginty, D. D. (1997) · Cell · doi:10.1016/s0092-8674(00)80535-8 · Cited by 1,180
Collapsin: A protein in brain that induces the collapse and paralysis of neuronal growth cones
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Neuropilin Is a Receptor for the Axonal Chemorepellent Semaphorin III
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The Indispensable Roles of Microglia and Astrocytes during Brain Development
Reemst, K., Noctor, S. C., Lucassen, P. J., & Hol, E. M. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00566 · Cited by 516
Conditional Loss of Dicer Disrupts Cellular and Tissue Morphogenesis in the Cortex and Hippocampus
Davis, T. H., Cuellar, T. L., Koch, S. M., Barker, A. J., Harfe, B. D., McManus, M. T., & Ullian, E. M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4815-07.2008 · Cited by 447
Semaphorin Regulation of Cellular Morphology
Tran, T. S., Kolodkin, A. L., & Bharadwaj, R. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.22.010605.093554 · Cited by 388
Le Naour, F., Hohenkirk, L., Grolleau, A., Misek, D. E., Lescure, P., Geiger, J. D., Hanash, S., & Beretta, L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100156200 · Cited by 284
Chondroitin sulfates and their binding molecules in the central nervous system
Djerbal, L., Lortat-Jacob, H., & Kwok, J. (2017) · Glycoconjugate Journal · doi:10.1007/s10719-017-9761-z · Cited by 144
Metadata
- Authors
- Bagnard, D., Lohrum, M., Uziel, D., Püschel, A. W., & Bolz, J.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1998-12-15
- Volume
- 125
- Issue
- 24
- Pages
- 5043-5053
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2135255676
- Cited by
- 346
- References
- 58
- FWCI
- 9.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bagnard, D., Lohrum, M., Uziel, D., Püschel, A. W., & Bolz, J. (1998). Semaphorins act as attractive and repulsive guidance signals during the development of cortical projections. Development. https://doi.org/10.1242/dev.125.24.5043
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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