The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
UNC-84 localizes to the nuclear envelope and is required for nuclear migration and anchoring during C. elegans development
Abstract
Nuclear migrations are essential for metazoan development. Two nuclear migrations that occur during C. elegans development require the function of the unc-84 gene. unc-84 mutants are also defective in the anchoring of nuclei within the hypodermal syncytium and in the migrations of the two distal tip cells of the gonad. Complementation analyses of 17 unc-84 alleles defined two genetically separable functions. Both functions are required for nuclear and distal tip cell migrations, but only one is required for nuclear anchorage. The DNA lesions associated with these 17 mutations indicate that the two genetically defined functions correspond to two distinct regions of the UNC-84 protein. The UNC-84 protein has a predicted transmembrane domain and a C-terminal region with similarity to the S. pombe spindle pole body protein Sad1 and to two predicted mammalian proteins. Analysis of a green fluorescent protein reporter indicated that UNC-84 is widely expressed and localized to the nuclear envelope. We propose that UNC-84 functions to facilitate a nuclear-centrosomal interaction required for nuclear migration and anchorage.
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Cites
The embryonic cell lineage of the nematode Caenorhabditis elegans
Sulston, J. E., Schierenberg, E., White, J. G., & Thomson, J. N. (1983) · Developmental Biology · doi:10.1016/0012-1606(83)90201-4 · Cited by 4,199
Genetic control of programmed cell death in the nematode C. elegans
Ellis, H. (1986) · Cell · doi:10.1016/0092-8674(86)90004-8 · Cited by 1,828
Cited by
The nuclear lamina comes of age
Gruenbaum, Y., Margalit, A., Goldman, R. D., Shumaker, D. K., & Wilson, K. L. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1550 · Cited by 834
Nuclear lamins: building blocks of nuclear architecture
Goldman, R. D., Gruenbaum, Y., Moir, R. D., Shumaker, D. K., & Spann, T. P. (2002) · Genes & Development · doi:10.1101/gad.960502 · Cited by 586
Haque, F., Lloyd, D. J., Smallwood, D. T., Dent, C. L., Shanahan, C. M., Fry, A. M., Trembath, R. C., & Shackleton, S. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.10.3738-3751.2006 · Cited by 503
Dittmer, T. A., & Misteli, T. (2011) · Genome Biology · doi:10.1186/gb-2011-12-5-222 · Cited by 481
Zhang, X., Lei, K., Yuan, X., Wu, X., Zhuang, Y., Xu, T., Xu, R., & Han, M. (2009) · Neuron · doi:10.1016/j.neuron.2009.08.018 · Cited by 462
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Metadata
- Authors
- Malone, C. J., Fixsen, W. D., Horvitz, H. R., & Han, M.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1999-07-15
- Volume
- 126
- Issue
- 14
- Pages
- 3171-3181
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1847371669
- Cited by
- 299
- References
- 2
- FWCI
- 3.37
- Type
- journal article
- Language
- en
- Open access
- closed
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