The DOI matches its Crossref record.
Role of Pax6 in development of the cerebellar system
Abstract
Post-mitotic neurons generated at the rhombic lip undertake long distance migration to widely dispersed destinations, giving rise to cerebellar granule cells and the precerebellar nuclei. Here we show that Pax6, a key regulator in CNS and eye development, is strongly expressed in rhombic lip and in cells migrating away from it. Development of some structures derived from these cells is severely affected in Pax6-null Small eye (Pax6Sey/Pax6Sey) embryos. Cell proliferation and initial differentiation seem unaffected, but cell migration and neurite extension are disrupted in mutant embryos. Three of the five precerebellar nuclei fail to form correctly. In the cerebellum the pre-migratory granule cell sub-layer and fissures are absent. Some granule cells are found in ectopic positions in the inferior colliculus which may result from the complete absence of Unc5h3 expression in Pax6Sey/Pax6Sey granule cells. Our results suggest that Pax6 plays a strong role during hindbrain migration processes and at least part of its activity is mediated through regulation of the netrin receptor Unc5h3.
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Cited by
Schüller, U., Heine, V. M., Mao, J., Kho, A. T., Dillon, A. K., Han, Y.-G., Huillard, E., Sun, T., Ligon, A. H., Qian, Y., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.07.005 · Cited by 667
Hevner, R. F., Hodge, R. D., Daza, R. A. M., & Englund, C. (2006) · Neuroscience Research · doi:10.1016/j.neures.2006.03.004 · Cited by 410
Osumi, N., Shinohara, H., Numayama-Tsuruta, K., & Maekawa, M. (2008) · Stem Cells · doi:10.1634/stemcells.2007-0884 · Cited by 344
Autoregulation and multiple enhancers control Math1 expression in the developing nervous system
Helms, A. W., Abney, A. L., Ben-Arie, N., Zoghbi, H. Y., & Johnson, J. E. (2000) · Development · doi:10.1242/dev.127.6.1185 · Cited by 289
Murakami, Y., Ogasawara, M., Sugahara, F., Hirano, S., Satoh, N., & Kuratani, S. (2001) · Development · doi:10.1242/dev.128.18.3521 · Cited by 202
Origin of the Precerebellar System
Rodriguez, C. I., & Dymecki, S. M. (2000) · Neuron · doi:10.1016/s0896-6273(00)00059-3 · Cited by 149
Evidence from cyclostomes for complex regionalization of the ancestral vertebrate brain
Sugahara, F., Pascual-Anaya, J., Oisi, Y., Kuraku, S., Aota, S.-I., Adachi, N., Takagi, W., Hirai, T., Sato, N., Murakami, Y., et al. (2016) · Nature · doi:10.1038/nature16518 · Cited by 121
Swanson, D. J., & Goldowitz, D. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2010.11.018 · Cited by 40
Metadata
- Authors
- Engelkamp, D., Rashbass, P., Seawright, A., & Heyningen, V. V.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1999-08-15
- Volume
- 126
- Issue
- 16
- Pages
- 3585-3596
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2118746463
- Cited by
- 292
- References
- 0
- FWCI
- 2.45
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
