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Transcription factors in glutamatergic neurogenesis: Conserved programs in neocortex, cerebellum, and adult hippocampus

Hevner, Robert F., Hodge, Rebecca D., Daza, Ray A.M., Englund, Chris·2006·Neuroscience Research
DOI 10.1016/j.neures.2006.03.004
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Abstract

Glutamatergic, pyramidal-projection neurons are produced in the embryonic cerebral cortex by a series of genetically programmed fate choices, implemented in large part by developmental transcription factors. Our work has focused on Pax6, Tbr2/Eomes, NeuroD, and Tbr1, which are expressed sequentially during the neurogenesis of pyramidal-projection neurons. Recently, we have found that the same transcription factors are expressed, in the same order, during glutamatergic neurogenesis in the adult dentate gyrus, and (with modifications) in the developing cerebellum. While the precise functional significance of this transcription factor expression sequence is unknown, its common appearance in embryonic and adult neurogenesis, and in different brain regions, suggests it is part of a conserved genetic program that specifies general properties of glutamatergic neurons in these regions. Subtypes of glutamatergic neurons (e.g., layer-specific fates in the cortex) are further determined by combinations of transcription factors, superimposed on general sequential programs. These new perspectives on neurogenesis add to the conceptual framework for strategies to engineer neural stem cells for the repair of specific brain circuits.

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  • RNA-seq of hippocampal tissues from middle-aged mice treated with TAC for 3 weeks induced a significant increase in expression of genes positively associated with adult hippocampus neurogenesis and brain function, including Eomes, Dlk1, Gdnf, Dcx, Sox1/2, Gdf11, and Fos.

    “Remarkably, TAC treatment induced a significant increase in the expression of genes positively associated with adult hippocampus neurogenesis and brain function,30–35 including Eomes, a driver of immune cell development & neurogenesis, Dlk1, a mediator of adult hippocampal neurogenesis and cognition, Gdnf, a neurotrophic factor, Dcx, a marker for new-born neurons, Sox1/2, critical determinants of”

    From TERT activation targets DNA methylation and multiple aging hallmarks (2024) · cites this paper as [33]

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Metadata

Authors
Hevner, R. F., Hodge, R. D., Daza, R. A. M., & Englund, C.
Venue
Neuroscience Research
Publisher
Elsevier BV
Published
2006-07
Volume
55
Issue
3
Pages
223-233
ISSN
0168-0102
DOI
10.1016/j.neures.2006.03.004
Cited by
410
References
6
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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