The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5
Abstract
The Dlx5 gene encodes a Distal-less-related DNA-binding homeobox protein first expressed during early embryonic development in anterior regions of the mouse embryo. In later developmental stages, it appears in the branchial arches, the otic and olfactory placodes and their derivatives, in restricted brain regions, in all extending appendages and in all developing bones. We have created a null allele of the mouse Dlx5 gene by replacing exons I and II with the E. coli lacZ gene. Heterozygous mice appear normal. β-galactosidase activity in Dlx5+/− embryos and newborn animals reproduces the known pattern of expression of the gene. Homozygous mutants die shortly after birth with a swollen abdomen. They present a complex phenotype characterised by craniofacial abnormalities affecting derivatives of the first four branchial arches, severe malformations of the vestibular organ, a delayed ossification of the roof of the skull and abnormal osteogenesis. No obvious defect was observed in the patterning of limbs and other appendages. The defects observed in Dlx5−/− mutant animals suggest multiple and independent roles of this gene in the patterning of the branchial arches, in the morphogenesis of the vestibular organ and in osteoblast differentiation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.
Gavrieli, Y., Sherman, Y., & Ben-Sasson, S. A. (1992) · The Journal of cell biology · doi:10.1083/jcb.119.3.493 · Cited by 9,444
Otto, F., Thornell, A. P., Crompton, T., Denzel, A., Gilmour, K. C., Rosewell, I. R., Stamp, G. W. H., Beddington, R. S. P., Mundlos, S., Olsen, B. R., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80259-7 · Cited by 2,814
Echelard, Y., Epstein, D. J., St-Jacques, B., Shen, L., Mohler, J., McMahon, J. A., & McMahon, A. P. (1993) · Cell · doi:10.1016/0092-8674(93)90627-3 · Cited by 2,154
Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector
Robertson, E., Bradley, A., Kuehn, M., & Evans, M. (1986) · Nature · doi:10.1038/323445a0 · Cited by 751
Rhombencephalic neural crest segmentation is preserved throughout craniofacial ontogeny
Köntges, G., & Lumsden, A. (1996) · Development · doi:10.1242/dev.122.10.3229 · Cited by 671
Segmental origin and migration of neural crest cells in the hindbrain region of the chick embryo
Lumsden, A., Sprawson, N., & Graham, A. (1991) · Development · doi:10.1242/dev.113.4.1281 · Cited by 625
Simeone, A., Acampora, D., Mallamaci, A., Stornaiuolo, A., D'Apice, M. R., Nigro, V., & Boncinelli, E. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05935.x · Cited by 617
Self-citationWinged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres
Xuan, S., Baptista, C. A., Balas, G., Tao, W., Soares, V. C., & Lai, E. (1995) · Neuron · doi:10.1016/0896-6273(95)90262-7 · Cited by 601
Bulfone, A., Puelles, L., Porteus, M., Frohman, M., Martin, G., & Rubenstein, J. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-07-03155.1993 · Cited by 574
The Embryonic Vertebrate Forebrain: the Prosomeric Model
Rubenstein, J. L. R., Martinez, S., Shimamura, K., & Puelles, L. (1994) · Science · doi:10.1126/science.7939711 · Cited by 535
Vital dye analysis of cranial neural crest cell migration in the mouse embryo
Serbedzija, G. N., Bronner-Fraser, M., & Fraser, S. E. (1992) · Development · doi:10.1242/dev.116.2.297 · Cited by 464
Qiu, M., Bulfone, A., Ghattas, I., Meneses, J. J., Christensen, L., Sharpe, P. T., Presley, R., Pedersen, R. A., & Rubenstein, J. L. R. (1997) · Developmental Biology · doi:10.1006/dbio.1997.8556 · Cited by 462
Bulfone, A., Smiga, S. M., Shimamura, K., Peterson, A., Puelles, L., & Rubenstein, J. L. R. (1995) · Neuron · doi:10.1016/0896-6273(95)90065-9 · Cited by 425
Distal-less encodes a homoeodomain protein required for limb development in Drosophila
Cohen, S. M., Brönner, G., Küttner, F., Jürgens, G., & Jäckle, H. (1989) · Nature · doi:10.1038/338432a0 · Cited by 388
Qiu, M., Bulfone, A., Martinez, S., Meneses, J. J., Shimamura, K., Pedersen, R. A., & Rubenstein, J. L. (1995) · Genes & Development · doi:10.1101/gad.9.20.2523 · Cited by 376
The role of Pax-1 in axial skeleton development
Wallin, J., Wilting, J., Koseki, H., Fritsch, R., Christ, B., & Balling, R. (1994) · Development · doi:10.1242/dev.120.5.1109 · Cited by 352
Trainor, P. A., & Tam, P. P. L. (1995) · Development · doi:10.1242/dev.121.8.2569 · Cited by 335
The zinc finger gene Krox20 regulates HoxB2 (Hox2.8) during hindbrain segmentation
Sham, M. H., Vesque, C., Nonchev, S., Marshall, H., Frain, M., Gupta, R. D., Whiting, J., Wilkinson, D., Charnay, P., & Krumlauf, R. (1993) · Cell · doi:10.1016/0092-8674(93)90659-e · Cited by 295
Ryoo, H. M. (1997) · Molecular Endocrinology · doi:10.1210/me.11.11.1681 · Cited by 281
Cloning and characterization of two members of the vertebrate Dlx gene family.
Simeone, A., Acampora, D., Pannese, M., D'Esposito, M., Stornaiuolo, A., Gulisano, M., Mallamaci, A., Kastury, K., Druck, T., & Huebner, K. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.6.2250 · Cited by 277
Self-citationHeterodimerization of Msx and Dlx Homeoproteins Results in Functional Antagonism
Zhang, H., Hu, G., Wang, H., Sciavolino, P., Iler, N., Shen, M. M., & Abate-Shen, C. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.5.2920 · Cited by 263
Signalling interactions during facial development
Francis-West, P., Ladher, R., Barlow, A., & Graveson, A. (1998) · Mechanisms of Development · doi:10.1016/s0925-4773(98)00082-3 · Cited by 242
Robinson, G. W., & Mahon, K. A. (1994) · Mechanisms of Development · doi:10.1016/0925-4773(94)90060-4 · Cited by 231
Liu, J. K., Ghattas, I., Liu, S., Chen, S., & Rubenstein, J. L. R. (1997) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(199712)210:4<498::aid-aja12>3.0.co;2-3 · Cited by 216
The evolution of the vertebrate Dlx gene family.
Stock, D. W., Ellies, D. L., Zhao, Z., Ekker, M., Ruddle, F. H., & Weiss, K. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.20.10858 · Cited by 216
Simeone, A., D'Apice, M. R., Nigro, V., Casanova, J., Graziani, F., Acampora, D., & Avantaggiato, V. (1994) · Neuron · doi:10.1016/0896-6273(94)90461-8 · Cited by 187
Self-citationInner ear and maternal reproductive defects in mice lacking the Hmx3 homeobox gene
Wang, W., Water, T. V. D., & Lufkin, T. (1998) · Development · doi:10.1242/dev.125.4.621 · Cited by 171
Nkx5-1 controls semicircular canal formation in the mouse inner ear
Hadrys, T., Braun, T. W., Rinkwitz, S., Arnold, H.-H., & Bober, E. (1998) · Development · doi:10.1242/dev.125.1.33 · Cited by 130
Self-citationScherer, S. W., Poorka, P., Massa, H. F., Soder, S., Allen, T., Nuñes, M. E., Geshurl, D., Wong, E., Bellonl, E., Little, S., et al. (1994) · Human Molecular Genetics · doi:10.1093/hmg/3.8.1345 · Cited by 124
An Early Phase of EmbryonicDlx5Expression Defines the Rostral Boundary of the Neural Plate
Yang, L., Zhang, H., Hu, G., Wang, H., Abate-Shen, C. T., & Shen, M. M. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-20-08322.1998 · Cited by 104
Sequence, Organization, and Transcription of theDlx-1andDlx-2Locus
McGuinness, T. L., Porteus, M. H., Smiga, S., Bulfone, A., Kingsley, C., Qiu, M. S., Liu, J. K., Long, J. E., Xu, D., & Rubenstein, J. L. R. (1996) · Genomics · doi:10.1006/geno.1996.0387 · Cited by 83
Zhao, G.-Q., Zhao, S., Zhou, X., et al. (1994) · Developmental Biology · doi:10.1006/dbio.1994.1178 · Cited by 81
Distal-less is a downstream gene of Deformed required for ventral maxillary identity
O’Hara, E., Cohen, B., Cohen, S. M., & McGinnis, W. J. (1993) · Development · doi:10.1242/dev.117.3.847 · Cited by 77
Genomic Analysis of a New Mammalian Distal-less Gene: Dlx7
Nakamura, S., Stock, D. W., Wydner, K. L., Bollekens, J. A., Takeshita, K., Nagai, B. M., Chiba, S., Kitamura, T., Freeland, T. M., Zhao, Z., et al. (1996) · Genomics · doi:10.1006/geno.1996.0634 · Cited by 75
Chapman, G., Remiszewski, J., Webb, G. C., Schulz, T. C., Bottema, C. D. K., & Rathjen, P. D. (1997) · Genomics · doi:10.1006/geno.1997.4969 · Cited by 43
Cleft hand/foot: clinical and developmental aspects.
Buss, P. W. (1994) · Journal of Medical Genetics · doi:10.1136/jmg.31.9.726 · Cited by 26
Cited by
A promoter-level mammalian expression atlas
The FANTOM Consortium and the RIKEN PMI and CLST (DGT) (2014) · Nature · doi:10.1038/nature13182 · Cited by 1,982
The Osteoblast: A Sophisticated Fibroblast under Central Surveillance
Ducy, P., Schinke, T., & Karsenty, G. (2000) · Science · doi:10.1126/science.289.5484.1501 · Cited by 1,120
Feng, J., Bi, C., Clark, B. S., Mady, R., Shah, P., & Kohtz, J. D. (2006) · Genes & Development · doi:10.1101/gad.1416106 · Cited by 712
Minoux, M., & Rijli, F. M. (2010) · Development · doi:10.1242/dev.040048 · Cited by 507
Specification of Jaw Subdivisions by Dlx Genes
Depew, M. J., Lufkin, T., & Rubenstein, J. L. R. (2002) · Science · doi:10.1126/science.1075703 · Cited by 465
Metadata
- Authors
- Acampora, D., Merlo, G. R., Paleari, L., Zerega, B., Postiglione, M. P., Mantero, S., Bober, E., Barbieri, O., Simeone, A., & Levi, G.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1999-09-01
- Volume
- 126
- Issue
- 17
- Pages
- 3795-3809
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2135144225
- Cited by
- 444
- References
- 36
- FWCI
- 7.39
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
