The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Pax6 induces ectopic eyes in a vertebrate
Abstract
We report here that misexpression of the transcription factor Pax6 in the vertebrate Xenopus laevis leads to the formation of differentiated ectopic eyes. Multiple molecular markers indicated the presence of mature lens fiber cells, ganglion cells, Müller cells, photoreceptors and retinal pigment epithelial cells in a spatial arrangement similar to that of endogenous eyes. Lineage tracing experiments showed that lens, retina and retinal pigment epithelium arose as a consequence of the cell-autonomous function of Pax6. These experiments also reveal that the cell autonomous activity of misexpressed Pax6 causes the ectopic expression of a number of genes including Rx, Otx2, Six3 and endogenous Pax6, each of which has been implicated in eye development. The formation of ectopic and endogenous eyes could be suppressed by coexpression of a dominant-negative form of Pax6. These data show that in vertebrates, as in the invertebrate Drosophila melanogaster, Pax6 is both necessary and sufficient to trigger the cascade of events required for eye formation.
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Cites
Homology of the eyeless Gene of Drosophila to the Small eye Gene in Mice and Aniridia in Humans
Quiring, R., Walldorf, U., Kloter, U., & Gehring, W. J. (1994) · Science · doi:10.1126/science.7914031 · Cited by 1,100
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Levin, M. (2021) · Cell · doi:10.1016/j.cell.2021.02.034 · Cited by 505
Patel, S. R., Kim, D., Levitan, I., & Dressler, G. R. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.09.004 · Cited by 249
Levin, M. (2022) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2022.768201 · Cited by 195
Arendt, D., Tessmar, K., de Campos-Baptista, M.-I. M., Dorresteijn, A., & Wittbrodt, J. (2002) · Development · doi:10.1242/dev.129.5.1143 · Cited by 192
Bailey, A. P., Bhattacharyya, S., Bronner-Fraser, M., & Streit, A. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.08.009 · Cited by 190
Metadata
- Authors
- Chow, R. L., Altmann, C. R., Lang, R. A., & Hemmati-Brivanlou, A.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1999-10-01
- Volume
- 126
- Issue
- 19
- Pages
- 4213-4222
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2121934176
- Cited by
- 451
- References
- 1
- FWCI
- 9.90
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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