The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
The transcription factor GATA6 is essential for early extraembryonic development
Open accessAbstract
The gene coding for the murine transcription factor GATA6 was inactivated by insertion of a β-galactosidase marker gene. The analysis of heterozygote GATA6/lacZ mice shows two inductions of GATA6 expression early in development. It is first expressed at the blastocyst stage in part of the inner cell mass and in the trophectoderm. The second wave of expression is in parietal endoderm (Reichert’s membrane) and the mesoderm and endoderm that form the heart and gut. Inactivation leads to a lethality shortly after implantation (5.5 days postcoitum). Chimeric experiments show this to be caused by an indirect effect on the epiblast due to a defect in an extraembryonic tissue.
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Pevny, L., Simon, M. C., Robertson, E., Klein, W. H., Tsai, S.-F., D'Agati, V., Orkin, S. H., & Costantini, F. (1991) · Nature · doi:10.1038/349257a0 · Cited by 1,308
GATA-4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut.
Laverriere, A. C., MacNeill, C., Mueller, C., Poelmann, R. E., Burch, J. B., & Evans, T. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31636-8 · Cited by 558
Weiss, M. J., Keller, G., & Orkin, S. H. (1994) · Genes & Development · doi:10.1101/gad.8.10.1184 · Cited by 541
Tsai, S. F., Strauss, E., & Orkin, S. H. (1991) · Genes & Development · doi:10.1101/gad.5.6.919 · Cited by 327
Heterochromatin Effects on the Frequency and Duration of LCR-Mediated Gene Transcription
Milot, E., Strouboulis, J., Trimborn, T., Wijgerde, M., de Boer, E., Langeveld, A., Tan-Un, K., Vergeer, W., Yannoutsos, N., Grosveld, F., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81327-6 · Cited by 314
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Cited by
Chazaud, C., Yamanaka, Y., Pawson, T., & Rossant, J. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.02.020 · Cited by 898
Distinct sequential cell behaviours direct primitive endoderm formation in the mouse blastocyst
Plusa, B., Piliszek, A., Frankenberg, S., Artus, J., & Hadjantonakis, A.-K. (2008) · Development · doi:10.1242/dev.021519 · Cited by 556
Pax6 is a human neuroectoderm cell fate determinant
Zhang, X., Huang, C. T., Chen, J., Pankratz, M. T., Xi, J., Li, J., Yang, Y., LaVaute, T. M., Li, X.-J., Ayala, M., et al. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.04.017 · Cited by 480
Boroviak, T., Loos, R., Bertone, P., Smith, A., & Nichols, J. (2014) · Nature Cell Biology · doi:10.1038/ncb2965 · Cited by 441
Hay, D. C., Sutherland, L., Clark, J., & Burdon, T. (2004) · Stem Cells · doi:10.1634/stemcells.22-2-225 · Cited by 375
Metadata
- Authors
- Koutsourakis, M., Langeveld, A., Patient, R., Beddington, R., & Grosveld, F.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1999-02-15
- Volume
- 126
- Issue
- 4
- Pages
- 723-732
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2142330433
- Cited by
- 461
- References
- 5
- FWCI
- 7.94
- Type
- journal article
- Language
- en
- Open access
- green
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- Koutsourakis, M., Langeveld, A., Patient, R., Beddington, R., & Grosveld, F. (1999). The transcription factor GATA6 is essential for early extraembryonic development. Development. https://doi.org/10.1242/dev.126.4.723
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
