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Cited by 87Developmental Biology and Gene RegulationEchinoderm biology and ecologyMarine Invertebrate Physiology and Ecology

A novel ontogenetic pathway in hybrid embryos between species with different modes of development

Raff, Elizabeth C., Popodi, Ellen M., Sly, Belinda J., Turner, F. Rudolf, Villinski, Jeffrey T., Raff, Rudolf A.·1999·Development
DOI 10.1242/dev.126.9.1937
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Abstract

To investigate the bases for evolutionary changes in developmental mode, we fertilized eggs of a direct-developing sea urchin, Heliocidaris erythrogramma, with sperm from a closely related species, H. tuberculata, that undergoes indirect development via a feeding larva. The resulting hybrids completed development to form juvenile adult sea urchins. Hybrids exhibited restoration of feeding larval structures and paternal gene expression that have been lost in the evolution of the direct-developing maternal species. However, the developmental outcome of the hybrids was not a simple reversion to the paternal pluteus larval form. An unexpected result was that the ontogeny of the hybrids was distinct from either parental species. Early hybrid larvae exhibited a novel morphology similar to that of the dipleurula-type larva typical of other classes of echinoderms and considered to represent the ancestral echinoderm larval form. In the hybrid developmental program, therefore, both recent and ancient ancestral features were restored. That is, the hybrids exhibited features of the pluteus larval form that is present in both the paternal species and in the immediate common ancestor of the two species, but they also exhibited general developmental features of very distantly related echinoderms. Thus in the hybrids, the interaction of two genomes that normally encode two disparate developmental modes produces a novel but harmonious ontongeny.

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  • The Raff et al. experiment shows that the evolution of direct development in the ancestors of H. erythrogramma involved disabling the genetic regulatory program required to generate the larva, which is rescued in the hybrid.

    “The experiment of Raff et al. (1999) shows that the evolution of direct development in the ancestors of H. erythrogramma involved the disabling of the genetic regulatory program required to generate the larva, which is rescued in the hybrid.”

    From Bilaterian Origins: Significance of New Experimental Observations (2000) · cites this paper as Raff et al., 1999

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Authors
Raff, E. C., Popodi, E. M., Sly, B. J., Turner, F. R., Villinski, J. T., & Raff, R. A.
Affiliations
Indiana University Bloomington (US)
ORCID
Popodi, Ellen M.
Venue
Development
Publisher
The Company of Biologists
Published
1999-05-01
Volume
126
Issue
9
Pages
1937-1945
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
DOI
10.1242/dev.126.9.1937
OpenAlex
W2128949069
Cited by
87
References
48
Citations by year
2024: 1 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 3 · 2013: 4 · 2012: 4
FWCI
1.71
Type
journal article
Language
en
Open access
closed
Licence
www.biologists.com/user-licence-1-1/ (vor)
Locations
  • Development (publishedVersion, public-domain)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Echinoderm biology and ecology
  • Physical Sciences › Earth and Planetary Sciences › Paleontology › Marine Invertebrate Physiology and Ecology
Keywords
interspecific hybridization, direct development, indirect development, Heliocidaris erythrogramma, Heliocidaris tuberculata, sea urchin embryonic development, pluteus larvae, paternal gene expression
MeSH terms
Animals, Embryo, Nonmammalian, Female, Hybridization, Genetic, Larva, Male, Microscopy, Electron, Scanning, Morphogenesis, Sea Urchins, Species Specificity, Gene Expression Regulation, Developmental

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