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Cited by 321

The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.

Opposing RA and FGF signals control proximodistal vertebrate limb development through regulation of Meis genes

Open access
Mercader, Nadia, Leonardo, Esther, Piedra, María Elisa, Martínez-A, Carlos, Ángeles Ros, María, Torres, Miguel·2000·Development
DOI 10.1242/dev.127.18.3961
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Abstract

Vertebrate limbs develop in a temporal proximodistal sequence, with proximal regions specified and generated earlier than distal ones. Whereas considerable information is available on the mechanisms promoting limb growth, those involved in determining the proximodistal identity of limb parts remain largely unknown. We show here that retinoic acid (RA) is an upstream activator of the proximal determinant genes Meis1 and Meis2. RA promotes proximalization of limb cells and endogenous RA signaling is required to maintain the proximal Meis domain in the limb. RA synthesis and signaling range, which initially span the entire lateral plate mesoderm, become restricted to proximal limb domains by the apical ectodermal ridge (AER) activity following limb initiation. We identify fibroblast growth factor (FGF) as the main molecule responsible for this AER activity and propose a model integrating the role of FGF in limb cell proliferation, with a specific function in promoting distalization through inhibition of RA production and signaling.

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Metadata

Authors
Mercader, N., Leonardo, E., Piedra, M. E., Martínez-A, C., Ángeles Ros, M., & Torres, M.
Venue
Development
Publisher
The Company of Biologists
Published
2000-09-15
Volume
127
Issue
18
Pages
3961-3970
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
DOI
10.1242/dev.127.18.3961
OpenAlex
W1939881246
Cited by
321
References
59
FWCI
3.27
Type
journal article
Language
en
Open access
green

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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