The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb
Abstract
Mice carrying a targeted disruption of BmprIB were generated by homologous recombination in embryonic stem cells. BmprIB−/− mice are viable and, in spite of the widespread expression of BMPRIB throughout the developing skeleton, exhibit defects that are largely restricted to the appendicular skeleton. Using molecular markers, we show that the initial formation of the digital rays occurs normally in null mutants, but proliferation of prechondrogenic cells and chondrocyte differentiation in the phalangeal region are markedly reduced. Our results suggest that BMPRIB-mediated signaling is required for cell proliferation after commitment to the chondrogenic lineage. Analyses of BmprIB and Gdf5 single mutants, as well as BmprIB; Gdf5 double mutants suggests that GDF5 is a ligand for BMPRIB in vivo. BmprIB; Bmp7 double mutants were constructed in order to examine whether BMPRIB has overlapping functions with other type I BMP receptors. BmprIB; Bmp7 double mutants exhibit severe appendicular skeletal defects, suggesting that BMPRIB and BMP7 act in distinct, but overlapping pathways. These results also demonstrate that in the absence of BMPRIB, BMP7 plays an essential role in appendicular skeletal development. Therefore, rather than having a unique role, BMPRIB has broadly overlapping functions with other BMP receptors during skeletal development.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Manipulating the mouse embryo: A laboratory manual
Hogan, B. L. M., Costantini, F. D., & Lacy, E. (1986) · Cited by 4,460
Manipulating the mouse embryo: A laboratory manual
Johnson, M. (1986) · Trends in Genetics · doi:10.1016/0168-9525(86)90275-1 · Cited by 2,245
Sox9 is required for cartilage formation
Bi, W., Deng, J. M., Zhang, Z., Behringer, R. R., & de Crombrugghe, B. (1999) · Nature Genetics · doi:10.1038/8792 · Cited by 1,758
A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye.
Dudley, A. T., Lyons, K. M., & Robertson, E. J. (1995) · Genes & Development · doi:10.1101/gad.9.22.2795 · Cited by 1,131
Self-citationLuo, G., Hofmann, C., Bronckers, A. L., Sohocki, M., Bradley, A., & Karsenty, G. (1995) · Genes & Development · doi:10.1101/gad.9.22.2808 · Cited by 1,021
SOX9 directly regulates the type-ll collagen gene
Bell, D. M., Leung, K. K. H., Wheatley, S. C., Ng, L. J., Zhou, S., Wing Ling, K., Har Sham, M., Koopman, P., Tam, P. P. L., & Cheah, K. S. E. (1997) · Nature Genetics · doi:10.1038/ng0697-174 · Cited by 933
Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1
Kretzschmar, M., Doody, J., & Massagu, J. (1997) · Nature · doi:10.1038/39348 · Cited by 877
Limb alterations in brachypodism mice due to mutations in a new member of the TGFβ-superfamily
Storm, E. E., Huynh, T. V., Copeland, N. G., Jenkins, N. A., Kingsley, D. M., & Lee, S.-J. (1994) · Nature · doi:10.1038/368639a0 · Cited by 854
Mishina, Y., Suzuki, A., Ueno, N., & Behringer, R. R. (1995) · Genes & Development · doi:10.1101/gad.9.24.3027 · Cited by 776
Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4.
ten Dijke, P., Yamashita, H., Sampath, T. K., Reddi, A. H., Estevez, M., Riddle, D. L., Ichijo, H., Heldin, C. H., & Miyazono, K. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32506-1 · Cited by 730
Cited by
Wu, M., Chen, G., & Li, Y.-P. (2016) · Bone Research · doi:10.1038/boneres.2016.9 · Cited by 1,553
BMP signalling in skeletal development, disease and repair
Salazar, V. S., Gamer, L. W., & Rosen, V. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.12 · Cited by 822
Self-citationGenetic Analysis of the Mammalian Transforming Growth Factor-β Superfamily
Chang, H., Brown, C. W., & Matzuk, M. M. (2002) · Endocrine Reviews · doi:10.1210/er.2002-0003 · Cited by 787
Systemic and Local Regulation of the Growth Plate
van der Eerden, B. C. J., Karperien, M., & Wit, J. M. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0033 · Cited by 558
Wilson, T., Wu, X.-Y., Juengel, J. L., Ross, I. K., Lumsden, J. M., Lord, E. A., Dodds, K. G., Walling, G. A., McEwan, J. C., O’Connell, A. R., et al. (2001) · Biology of Reproduction · doi:10.1095/biolreprod64.4.1225 · Cited by 548
Metadata
- Authors
- Yi, S. E., Daluiski, A., Pederson, R., Rosen, V., & Lyons, K. M.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2000-02-01
- Volume
- 127
- Issue
- 3
- Pages
- 621-630
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1922697055
- Cited by
- 385
- References
- 40
- FWCI
- 9.58
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb. https://app.cochat.ai/papers/10.1242/dev.127.3.621
- The paper
- Yi, S. E., Daluiski, A., Pederson, R., Rosen, V., & Lyons, K. M. (2000). The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb. Development. https://doi.org/10.1242/dev.127.3.621
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
