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Cited by 98Developmental Biology and Gene RegulationNeurobiology and Insect Physiology ResearchWnt/β-catenin signaling in development and cancer

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Combined activities of Gurken and Decapentaplegic specify dorsal chorion structures of the Drosophila egg

Peri, Francesca, Roth, Siegfried·2000·Development
DOI 10.1242/dev.127.4.841
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Abstract

During Drosophila oogenesis Gurken, associated with the oocyte nucleus, activates the Drosophila EGF receptor in the follicular epithelium. Gurken first specifies posterior follicle cells, which in turn signal back to the oocyte to induce the migration of the oocyte nucleus from a posterior to an anterior-dorsal position. Here, Gurken signals again to specify dorsal follicle cells, which give rise to dorsal chorion structures including the dorsal appendages. If Gurken signaling is delayed and starts after stage 6 of oogenesis the nucleus remains at the posterior pole of the oocyte. Eggs develop with a posterior ring of dorsal appendage material that is produced by main-body follicle cells expressing the gene Broad-Complex. They encircle terminal follicle cells expressing variable amounts of the TGFbeta homologue, decapentaplegic. By ectopically expressing decapentaplegic and clonal analysis with Mothers against dpp we show that Decapentaplegic signaling is required for Broad-Complex expression. Thus, the specification and positioning of dorsal appendages along the anterior-posterior axis depends on the intersection of both Gurken and Decapentaplegic signaling. This intersection also induces rhomboid expression and thereby initiates the positive feedback loop of EGF receptor activation, which positions the dorsal appendages along the dorsal-ventral egg axis.

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  • If nuclear movement is prevented, as in mago mutants or when the Grk signal is delayed, eggs develop with a normal AP axis but lack DV polarity orthogonal to the AP axis.

    “If nuclear movement is prevented as in mutants of mago or when the Grk signal is delayed, eggs develop that have a normal AP axis, but lack DV polarity orthogonal to the AP axis (figure 3b; Micklem et al. 1997; Peri & Roth 2000).”

    From The origin of dorsoventral polarity in Drosophila (2003) · cites this paper as Peri & Roth 2000

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References 47 · Cited by 98

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Metadata

Authors
Peri, F., & Roth, S.
Affiliations
University of Cologne (DE)
Corresponding author
Roth, Siegfried
ORCID
Venue
Development
Publisher
The Company of Biologists
Published
2000-02-15
Volume
127
Issue
4
Pages
841-850
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
DOI
10.1242/dev.127.4.841
OpenAlex
W2171483658
Cited by
98
References
47
Citations by year
2025: 1 · 2024: 1 · 2023: 4 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 6 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 8 · 2012: 4
FWCI
2.77
Type
journal article
Language
en
Open access
closed
Licence
www.biologists.com/user-licence-1-1/ (vor)
Locations
  • Development (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Keywords
Gurken, decapentaplegic, dorsal appendage, Drosophila oogenesis, EGF receptor signaling, follicle cells, Broad-Complex, TGF-beta signaling, rhomboid, anterior-posterior axis, dorsal-ventral axis
MeSH terms
Animals, Drosophila, Female, Mosaicism, Oocytes, Oogenesis, Phenotype, Transforming Growth Factors, Signal Transduction, Transforming Growth Factor alpha, Cell Polarity, Genes, Insect, Gene Expression Regulation, Developmental, Insect Proteins, Drosophila Proteins, Animals, Genetically Modified

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