The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Functional conservation of atonal and Math1 in the CNS and PNS
Abstract
To determine the extent to which atonal and its mouse homolog Math1 exhibit functional conservation, we inserted β-galactosidase (lacZ) into the Math1 locus and analyzed its expression, evaluated consequences of loss of Math1 function, and expressed Math1 in atonal mutant flies. lacZ under the control of Math1 regulatory elements duplicated the previously known expression pattern of Math1 in the CNS (i.e., the neural tube, dorsal spinal cord, brainstem, and cerebellar external granule neurons) but also revealed new sites of expression: PNS mechanoreceptors (inner ear hair cells and Merkel cells) and articular chondrocytes. Expressing Math1 induced ectopic chordotonal organs (CHOs) in wild-type flies and partially rescued CHO loss in atonal mutant embryos. These data demonstrate that both the mouse and fly homologs encode lineage identity information and, more interestingly, that some of the cells dependent on this information serve similar mechanoreceptor functions.
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Citations
Cites
The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation
Davis, R. L., Cheng, P.-F., Lassar, A. B., & Weintraub, H. (1990) · Cell · doi:10.1016/0092-8674(90)90088-v · Cited by 765
Cited by
Math1 Is Expressed in Temporally Discrete Pools of Cerebellar Rhombic-Lip Neural Progenitors
Machold, R., & Fishell, G. (2005) · Neuron · doi:10.1016/j.neuron.2005.08.028 · Cited by 580
Smaller inner ear sensory epithelia in Neurog1 null mice are related to earlier hair cell cycle exit
Matei, V., Pauley, S., Kaing, S., Rowitch, D., Beisel, K. W., Morris, K., Feng, F., Jones, K., Lee, J., & Fritzsch, B. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20551 · Cited by 435
Math1-driven GFP expression in the developing nervous system of transgenic mice
Lumpkin, E. A., Collisson, T., Parab, P., Omer-Abdalla, A., Haeberle, H., Chen, P., Doetzlhofer, A., White, P., Groves, A., Segil, N., et al. (2003) · Gene Expression Patterns · doi:10.1016/s1567-133x(03)00089-9 · Cited by 292
Gastric pouches and the mucociliary sole: setting the stage for nervous system evolution
Arendt, D., Benito-Gutierrez, E., Brunet, T., & Marlow, H. (2015) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2015.0286 · Cited by 112
Jenkins, B. A., & Lumpkin, E. A. (2017) · Development · doi:10.1242/dev.120402 · Cited by 79
Metadata
- Authors
- Ben-Arie, N., Hassan, B. A., Bermingham, N. A., Malicki, D. M., Armstrong, D., Matzuk, M., Bellen, H. J., & Zoghbi, H. Y.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2000-03-01
- Volume
- 127
- Issue
- 5
- Pages
- 1039-1048
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2143331812
- Cited by
- 258
- References
- 1
- FWCI
- 5.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ben-Arie, N., Hassan, B. A., Bermingham, N. A., Malicki, D. M., Armstrong, D., Matzuk, M., Bellen, H. J., & Zoghbi, H. Y. (2000). Functional conservation of atonal and Math1 in the CNS and PNS. Development. https://doi.org/10.1242/dev.127.5.1039
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